{"id":"W3200596350","doi":"10.1212/wnl.94.15_supplement.1770","title":"Safety and Tolerability of Ponesimod Compared to Teriflunomide in Patients with Relapsing Multiple Sclerosis: Results of the Randomized, Active-Controlled, Double-Blind, Parallel-Group Phase 3 OPTIMUM Study (1770)","year":2020,"lang":"en","type":"article","venue":"Neurology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital; Ottawa Hospital; University of Ottawa","funders":"","keywords":"Tolerability; Teriflunomide; Medicine; Double blind; Multiple sclerosis; Randomized controlled trial; Internal medicine; Adverse effect; Psychiatry; Alternative medicine; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001438072,0.0007282603,0.002217938,0.0003082135,0.0002535944,0.0005397867,0.0004917544,0.000830176,0.002550851],"category_scores_gemma":[0.001457321,0.000416216,0.001295115,0.0002419563,0.000712519,0.0007562551,0.0002682664,0.001865063,0.0003355151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003609524,"about_ca_system_score_gemma":0.0007864243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004144858,"about_ca_topic_score_gemma":0.0009811588,"domain_scores_codex":[0.9996293,0.0002018103,0.0000302374,0.00004393054,0.00003825939,0.00005645589],"domain_scores_gemma":[0.9991013,0.0002234942,0.0003113543,0.00006167988,0.00004988195,0.0002523449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9489718,0.005611522,0.00272393,0.0004421964,0.0008901565,0.00005276008,0.00006551792,0.0004673443,0.01561172,0.00006966184,0.0004997623,0.0245935],"study_design_scores_gemma":[0.7107987,0.2618256,0.02157157,0.00004221902,0.001030508,0.0001910386,0.0000470857,0.0006655036,0.002796362,0.0001658226,0.0008278619,0.00003768196],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959769,0.002141926,0.0003128773,0.0001301138,0.00004373623,0.0004090393,0.0003966485,0.00003811251,0.0005507617],"genre_scores_gemma":[0.995395,0.001303446,0.001045138,0.0003037278,0.0001360211,0.00052693,0.0007043639,0.0000194474,0.0005659019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002550851,"threshold_uncertainty_score":0.008533418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02348997573196909,"score_gpt":0.2465838852255132,"score_spread":0.2230939094935441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}