{"id":"W3200644065","doi":"10.1186/s12969-021-00588-0","title":"Colchicine – an effective treatment for children with a clinical diagnosis of autoinflammatory diseases without pathogenic gene variants","year":2021,"lang":"en","type":"article","venue":"Pediatric Rheumatology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital","funders":"Universitätsklinikum Tübingen","keywords":"Medicine; Colchicine; Familial Mediterranean fever; Internal medicine; Rheumatology; Cohort; Dosing; Disease; Physical therapy; Pediatrics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003302635,0.0001804967,0.00049397,0.0002894797,0.0002245283,0.0002233633,0.0001820678,0.0001918349,0.001915735],"category_scores_gemma":[0.0007839947,0.00008352502,0.0003033422,0.0004051669,0.0002362504,0.0002051829,0.000154365,0.0002697377,0.0002148752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000381883,"about_ca_system_score_gemma":0.0005048701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001144251,"about_ca_topic_score_gemma":0.003444948,"domain_scores_codex":[0.9996854,0.000113015,0.00003435907,0.00005714545,0.00007529802,0.00003477854],"domain_scores_gemma":[0.9993455,0.0001515564,0.0003238836,0.0000283066,0.00004817517,0.0001026012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02126712,0.002110348,0.8216796,0.001393147,0.0005708935,0.004275247,0.0004599024,0.0003654971,0.02293497,0.0001580506,0.003226167,0.1215591],"study_design_scores_gemma":[0.001124787,0.02089872,0.9617535,0.0001530144,0.0002591252,0.007277917,0.0002852438,0.0001382046,0.00259224,0.00003378365,0.005469756,0.00001360032],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906051,0.006198022,0.0001976849,0.0001118354,0.00002130484,0.0001681921,0.0007102164,0.00001147369,0.001976382],"genre_scores_gemma":[0.9959646,0.002247984,0.0006371902,0.00009930101,0.00003587716,0.0001277395,0.000539417,0.000004112671,0.0003437418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001915735,"threshold_uncertainty_score":0.006408751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007840014590264243,"score_gpt":0.2729320130487143,"score_spread":0.2650919984584501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}