{"id":"W3200644065","doi":"10.1186/s12969-021-00588-0","title":"Colchicine – an effective treatment for children with a clinical diagnosis of autoinflammatory diseases without pathogenic gene variants","year":2021,"lang":"en","type":"article","venue":"Pediatric Rheumatology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital","funders":"Universitätsklinikum Tübingen","keywords":"Medicine; Colchicine; Familial Mediterranean fever; Internal medicine; Rheumatology; Cohort; Dosing; Disease; Physical therapy; Pediatrics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001672845,0.0002440852,0.0006212589,0.00006271643,0.00008953427,0.000009042637,0.0001455791,0.0002159145,0.00001571801],"category_scores_gemma":[0.0002527024,0.0002020815,0.0002191361,0.0001262104,0.0001160935,0.00000759714,0.00006203298,0.00006166095,0.000003915034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001412431,"about_ca_system_score_gemma":0.0004178818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003289682,"about_ca_topic_score_gemma":0.00007470738,"domain_scores_codex":[0.9982409,0.0002594064,0.0005383305,0.0005548251,0.00008806928,0.0003184561],"domain_scores_gemma":[0.9987859,0.0001156483,0.0002872585,0.0004991261,0.0001990738,0.0001130655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006432165,0.0006831589,0.9875423,0.00004477833,0.0004107992,0.000008780238,0.00005529332,0.00002839999,0.002429793,0.00004440409,0.0001447423,0.007964291],"study_design_scores_gemma":[0.006800102,0.003572313,0.9708125,0.000009651824,0.0006199972,0.0001499338,0.00005450774,0.00003504935,0.01708951,0.00004413823,0.0004812035,0.0003311187],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919841,0.005981651,0.0008227861,0.00003935436,0.0001721635,0.0007804676,0.0001835653,0.00001910249,0.0000167632],"genre_scores_gemma":[0.9894394,0.007939264,0.0008454385,0.00004460705,0.000148108,0.000570175,0.0009321535,0.00004096715,0.00003987786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01672987,"threshold_uncertainty_score":0.8240643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007840014590264243,"score_gpt":0.2729320130487143,"score_spread":0.2650919984584501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}