{"id":"W3200678711","doi":"10.1038/s41598-021-97434-w","title":"Carboplatin response in preclinical models for ovarian cancer: comparison of 2D monolayers, spheroids, ex vivo tumors and in vivo models","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Institute of Cancer Research; Institut Du Cancer de Montréal; Université de Montréal; Canadian Institutes of Health Research; Ovarian Cancer Canada","keywords":"Ex vivo; Carboplatin; In vivo; Spheroid; Ovarian cancer; Medicine; Cancer research; Cancer; Cell culture; Pharmacology; Biology; Chemotherapy; Internal medicine; Cisplatin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001076946,0.0006915132,0.0007661193,0.001116166,0.000255749,0.0007057327,0.0003230867,0.0005652641,0.0009724573],"category_scores_gemma":[0.0007099383,0.0003644285,0.0005834745,0.0008211714,0.0003580922,0.0008274257,0.0004074158,0.001220881,0.0003009209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005457345,"about_ca_system_score_gemma":0.000384672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002151645,"about_ca_topic_score_gemma":0.003137772,"domain_scores_codex":[0.9991447,0.0003249963,0.0001278775,0.0001268423,0.0002060445,0.000069522],"domain_scores_gemma":[0.9990665,0.0003604655,0.0001776967,0.0001558385,0.000150923,0.00008859615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006216307,0.0003717295,0.002363323,0.000218623,0.00003705307,0.00006641777,0.000130259,0.0009533984,0.9914907,0.00009396612,0.0001842591,0.003468816],"study_design_scores_gemma":[0.00005083029,0.003093609,0.01867533,0.00001809325,0.0000751605,0.0002994673,0.0002062355,0.004527518,0.9705117,0.00008058409,0.002436308,0.00002516894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9572476,0.01041477,0.02443077,0.000387703,0.0001658274,0.0003733856,0.002739472,0.0003179649,0.003922617],"genre_scores_gemma":[0.9676555,0.006153591,0.01871352,0.0002172355,0.00004719971,0.0004116194,0.003111554,0.0001404784,0.00354922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002151645,"threshold_uncertainty_score":0.005695522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07361141407930186,"score_gpt":0.3603063380156127,"score_spread":0.2866949239363109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}