{"id":"W3200678711","doi":"10.1038/s41598-021-97434-w","title":"Carboplatin response in preclinical models for ovarian cancer: comparison of 2D monolayers, spheroids, ex vivo tumors and in vivo models","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Institute of Cancer Research; Institut Du Cancer de Montréal; Université de Montréal; Canadian Institutes of Health Research; Ovarian Cancer Canada","keywords":"Ex vivo; Carboplatin; In vivo; Spheroid; Ovarian cancer; Medicine; Cancer research; Cancer; Cell culture; Pharmacology; Biology; Chemotherapy; Internal medicine; Cisplatin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002582568,0.0001709239,0.0007592575,0.000214736,0.00005677112,0.00005324143,0.0000648358,0.000114974,0.0001120336],"category_scores_gemma":[0.0003088675,0.0001665791,0.0001287491,0.0006374524,0.0001629203,0.0001580646,0.00008004771,0.0001917562,2.093546e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001475051,"about_ca_system_score_gemma":0.001186586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001253913,"about_ca_topic_score_gemma":0.003394361,"domain_scores_codex":[0.996963,0.0001212674,0.00121494,0.0009081113,0.0004360999,0.0003565626],"domain_scores_gemma":[0.9983607,0.000176625,0.0003570566,0.0007074256,0.0002128106,0.0001853872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01111269,0.001963648,0.0963986,0.001183527,0.0001728572,0.002842814,0.01194972,0.1756569,0.6664873,0.0002537711,0.01543276,0.01654541],"study_design_scores_gemma":[0.006044385,0.0004122436,0.006130484,0.001724886,0.0002782388,0.0004040538,0.003297836,0.3636595,0.5922996,0.01460556,0.01047363,0.0006694904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99259,0.003341191,0.0009777441,0.0003489884,0.001276581,0.000766634,0.00003810962,0.00001611649,0.0006446419],"genre_scores_gemma":[0.9933777,0.00007511906,0.004234691,0.00003418649,0.00003886803,0.00007549879,0.00001490794,0.00002332871,0.002125636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1880027,"threshold_uncertainty_score":0.6792898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07361141407930186,"score_gpt":0.3603063380156127,"score_spread":0.2866949239363109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}