{"id":"W3200717490","doi":"10.1016/s1470-2045(21)00428-9","title":"Maintenance with daratumumab or observation following treatment with bortezomib, thalidomide, and dexamethasone with or without daratumumab and autologous stem-cell transplant in patients with newly diagnosed multiple myeloma (CASSIOPEIA): an open-label, randomised, phase 3 trial","year":2021,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":175,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotel Dieu Hospital","funders":"Janssen Research and Development","keywords":"Daratumumab; Medicine; Autologous stem-cell transplantation; Multiple myeloma; Thalidomide; Bortezomib; Internal medicine; Interim analysis; Clinical endpoint; Oncology; Dexamethasone; Progression-free survival; Surgery; Randomized controlled trial; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005885825,0.0005926057,0.002022199,0.0001161772,0.000371983,0.0001522772,0.0002553338,0.0001823147,0.00002485118],"category_scores_gemma":[0.00008036115,0.0002489222,0.00003153806,0.0005005665,0.0003753719,0.0004192643,0.00007502619,0.0004129843,0.000001675271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004011802,"about_ca_system_score_gemma":0.001349682,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008505758,"about_ca_topic_score_gemma":0.0252912,"domain_scores_codex":[0.9962273,0.000889503,0.0005113083,0.0009859313,0.0005040168,0.0008819085],"domain_scores_gemma":[0.997197,0.001116503,0.0003243405,0.00075986,0.0001998675,0.0004024636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7595892,0.00585119,0.1935944,0.00008891091,0.0007391762,0.008471075,0.001521795,0.000011414,0.0002623659,0.000006455414,0.00002259017,0.02984139],"study_design_scores_gemma":[0.834258,0.09204221,0.06804283,0.0005210339,0.0007715168,0.0006332262,0.0008276388,0.001325846,0.0006656843,0.000002690434,0.0005335549,0.0003757502],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906867,0.0002793636,0.0002839922,0.0007157178,0.00006172888,0.007519964,0.0001278016,0.00006202256,0.0002627059],"genre_scores_gemma":[0.9838206,0.0003833555,0.01273556,0.0002938561,0.00008512032,0.001538166,0.0003646566,0.00008590891,0.0006928387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1255516,"threshold_uncertainty_score":0.9999963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09038015065881295,"score_gpt":0.364344931942175,"score_spread":0.2739647812833621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}