{"id":"W3200717490","doi":"10.1016/s1470-2045(21)00428-9","title":"Maintenance with daratumumab or observation following treatment with bortezomib, thalidomide, and dexamethasone with or without daratumumab and autologous stem-cell transplant in patients with newly diagnosed multiple myeloma (CASSIOPEIA): an open-label, randomised, phase 3 trial","year":2021,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":175,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotel Dieu Hospital","funders":"Janssen Research and Development","keywords":"Daratumumab; Medicine; Autologous stem-cell transplantation; Multiple myeloma; Thalidomide; Bortezomib; Internal medicine; Interim analysis; Clinical endpoint; Oncology; Dexamethasone; Progression-free survival; Surgery; Randomized controlled trial; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001768234,0.001677943,0.003345195,0.0003674906,0.0005252866,0.001299358,0.0009326751,0.001831325,0.005272604],"category_scores_gemma":[0.001442309,0.0005988639,0.003175437,0.0004600133,0.00140145,0.001406489,0.0005054194,0.004397444,0.0008907591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001100487,"about_ca_system_score_gemma":0.00112541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002118703,"about_ca_topic_score_gemma":0.004225967,"domain_scores_codex":[0.9994081,0.0002662578,0.00003664337,0.0001338904,0.00003403786,0.0001210119],"domain_scores_gemma":[0.9990655,0.0002836152,0.0002177216,0.00007940063,0.00003969015,0.0003141887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9835604,0.001972032,0.000616152,0.0004039926,0.001002188,0.00002706313,0.00004974819,0.0002214923,0.0009367827,0.00006856149,0.000415006,0.0107265],"study_design_scores_gemma":[0.9545319,0.04203885,0.001936224,0.00003641318,0.0005468051,0.00003348801,0.00001931451,0.0001842684,0.0001576273,0.0001230428,0.0003810964,0.00001097101],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986003,0.008416796,0.0003671556,0.0008345766,0.0007750189,0.00130106,0.0007362339,0.00009162745,0.001474494],"genre_scores_gemma":[0.9901249,0.003492033,0.0007744067,0.0009849492,0.0004871785,0.001167562,0.0009635754,0.00001635365,0.001988866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005272604,"threshold_uncertainty_score":0.01763862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09038015065881295,"score_gpt":0.364344931942175,"score_spread":0.2739647812833621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}