{"id":"W3200729455","doi":"10.1080/2162402x.2021.1939518","title":"Phased differentiation of γδ T and T CD8 tumor-infiltrating lymphocytes revealed by single-cell transcriptomics of human cancers","year":2021,"lang":"en","type":"article","venue":"OncoImmunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche","keywords":"CD8; Cytotoxic T cell; Biology; Cancer research; T cell; Immune system; Transcriptome; Immunophenotyping; Immunology; Cancer immunotherapy; Tumor-infiltrating lymphocytes; Immunotherapy; Antigen; Gene expression; Gene; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001058095,0.0001667166,0.0004454484,0.0001032291,0.0001230806,0.000007595895,0.0001004087,0.0002150796,0.0008311958],"category_scores_gemma":[0.00005645768,0.0001753645,0.00009914778,0.0001253723,0.0002551787,0.0001010212,0.00002455312,0.0002131702,0.00001023227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001356613,"about_ca_system_score_gemma":0.0001230476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004121301,"about_ca_topic_score_gemma":0.0000470451,"domain_scores_codex":[0.9986792,0.000253603,0.0005638093,0.0002535869,0.0000308934,0.0002189301],"domain_scores_gemma":[0.9990574,0.0001255694,0.0004135752,0.0002280139,0.0001645989,0.00001084927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002277669,0.0002728412,0.001659254,0.00006609972,0.0001549389,0.000001075012,0.0005974921,0.000001817835,0.9943682,0.0001664199,0.0009787242,0.001505361],"study_design_scores_gemma":[0.003219881,0.0005807344,0.00163696,0.00006304682,0.00007952808,0.00006153166,0.001224284,0.000007572146,0.9860178,0.00002804716,0.006938509,0.0001421444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850658,0.009926235,0.0003332597,0.00006154176,0.001270571,0.0001115106,0.00002254726,0.00003115108,0.003177413],"genre_scores_gemma":[0.9957871,0.0002909443,0.0000514788,0.00008382136,0.00001009374,0.000009212835,0.000335777,0.0000171445,0.003414367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01072139,"threshold_uncertainty_score":0.9101011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01248047606255111,"score_gpt":0.2282348431543023,"score_spread":0.2157543670917511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}