{"id":"W3200748607","doi":"10.21203/rs.3.rs-885196/v1","title":"Dysregulation of Grainyhead-like 3 expression causes widespread developmental defects","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Transgene; Biology; Conditional gene knockout; Phenotype; Ectopic expression; Cell biology; Loss function; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001847016,0.0005140238,0.0003819742,0.0005612831,0.000214507,0.0003054386,0.0003076008,0.0005297477,0.002243538],"category_scores_gemma":[0.0001554542,0.0002559073,0.0003844401,0.0002207054,0.0004595043,0.0001408956,0.000416051,0.0006969572,0.0005731201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003404316,"about_ca_system_score_gemma":0.0002115511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006349615,"about_ca_topic_score_gemma":0.001237137,"domain_scores_codex":[0.999688,0.0000269504,0.00003996588,0.00007769467,0.0001058394,0.00006164862],"domain_scores_gemma":[0.9997149,0.00004696444,0.0001157044,0.00002953838,0.0000118743,0.00008095991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000590386,0.00001951212,0.0001700888,0.00001488248,0.000005499506,0.0001743991,0.000008955742,0.00004761671,0.9989716,0.0000605663,0.00004602976,0.0004218961],"study_design_scores_gemma":[0.00005291508,0.0003794953,0.01089478,0.00001337722,0.00004422228,0.001699687,0.00006020342,0.001081139,0.9827316,0.0001167597,0.002913592,0.00001221613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910299,0.0008687956,0.004660399,0.0001165796,0.00005744639,0.00004528299,0.001489964,0.00046659,0.001265094],"genre_scores_gemma":[0.9918972,0.000603904,0.002099173,0.0001021557,0.00001121632,0.0000499454,0.0008443713,0.0001276281,0.004264426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002243538,"threshold_uncertainty_score":0.007505417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03229114389429488,"score_gpt":0.3360193369322166,"score_spread":0.3037281930379218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}