{"id":"W3200771841","doi":"10.1101/2021.09.09.459689","title":"Targeting the Cx26/NANOG/Focal Adhesion Kinase Complex via Cell-Penetrating Peptides in Triple-Negative Breast Cancers","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact","funders":"Fogarty International Center; National Institutes of Health; U.S. Department of Defense","keywords":"Homeobox protein NANOG; Biology; Focal adhesion; Cancer research; Triple-negative breast cancer; Cell biology; Cell growth; Molecular biology; Signal transduction; Cancer; Biochemistry; Embryonic stem cell; Breast cancer; Induced pluripotent stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001354554,0.0002506562,0.0002663186,0.0001073046,0.00008697425,0.0001890792,0.000129899,0.0003062519,0.0004731227],"category_scores_gemma":[0.00007460722,0.00009909007,0.0001665452,0.00007021476,0.0001591718,0.0001545165,0.0001790264,0.0003461803,0.0001419597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002072557,"about_ca_system_score_gemma":0.00008612334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001953444,"about_ca_topic_score_gemma":0.0002512517,"domain_scores_codex":[0.999913,0.00001675765,0.000006705594,0.00001692252,0.00002462658,0.00002198757],"domain_scores_gemma":[0.9999567,0.000007557716,0.00001295963,0.000003867407,0.000005515934,0.00001342765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005040194,0.0000163436,0.0000486949,0.00002965253,0.000003810531,0.00005110186,0.000007914044,0.0001342641,0.9989395,0.00004764316,0.00002179425,0.0006489689],"study_design_scores_gemma":[0.00003068815,0.0006557396,0.001458282,0.000006184493,0.00001810742,0.0005504769,0.00002046351,0.001855218,0.9936592,0.00004573065,0.00169423,0.000005653839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959959,0.0009292004,0.002419254,0.00005813548,0.00001864084,0.0000394785,0.00005792607,0.00002606484,0.0004553953],"genre_scores_gemma":[0.9957318,0.000500271,0.002899071,0.00006487827,0.000005315643,0.00003558126,0.00007827798,0.000006327658,0.0006784348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004731227,"threshold_uncertainty_score":0.001582742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01222481631438658,"score_gpt":0.2247326094389188,"score_spread":0.2125077931245322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}