{"id":"W3200817173","doi":"10.1113/jp282107","title":"The suitability of high throughput automated patch clamp for physiological applications","year":2021,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"H. Lundbeck A/S; RWTH Aachen University; Institute for Molecular Bioscience, University Of Queensland; Lundbeckfonden","keywords":"Throughput; Patch clamp; Ion channel; Current clamp; High-throughput screening; Voltage clamp","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001445504,0.0006112637,0.0006535866,0.000501443,0.0003557164,0.001834515,0.001802456,0.001148308,0.005931148],"category_scores_gemma":[0.00187784,0.0004207358,0.0005061093,0.0004000491,0.0005118721,0.001693046,0.0007728906,0.001191104,0.003726611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006243727,"about_ca_system_score_gemma":0.0004242397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005841606,"about_ca_topic_score_gemma":0.0007418013,"domain_scores_codex":[0.9982979,0.0002518476,0.0001456515,0.0004330326,0.0007673622,0.0001043097],"domain_scores_gemma":[0.9981072,0.0007409959,0.0001278273,0.0005193524,0.0004310529,0.00007359986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002311383,0.00006741213,0.0006589736,0.0003156352,0.00005867994,0.0001229677,0.00005801797,0.001607124,0.9585438,0.001554399,0.0020054,0.03477628],"study_design_scores_gemma":[0.00006414762,0.0006807097,0.005749687,0.00008631544,0.00008863462,0.0008966468,0.00009975328,0.0388901,0.9216263,0.00233215,0.02940468,0.00008071521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1639544,0.005141118,0.8027534,0.002459277,0.0007278702,0.0006611318,0.003678425,0.01081351,0.009810841],"genre_scores_gemma":[0.6068572,0.004577915,0.3728203,0.0008984565,0.0003610699,0.001248456,0.00253945,0.0007978816,0.009899279],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005931148,"threshold_uncertainty_score":0.01984161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05542333451014431,"score_gpt":0.3508626427574801,"score_spread":0.2954393082473358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}