{"id":"W3200817283","doi":"10.1101/2021.09.13.460073","title":"Addition of a carboxy terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University","funders":"Canadian Institutes of Health Research; University of Bristol; Consejo Nacional de Ciencia y Tecnología; McGill University","keywords":"GNRHR; Luteinizing hormone; Endocrinology; Internal medicine; Gonadotropin-releasing hormone; Ovulation; Biology; Gonadotropic cell; Gonadotropin; Hormone; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004814106,0.001140715,0.0005133728,0.001608952,0.0003488794,0.0008293324,0.0008462544,0.00161352,0.007481625],"category_scores_gemma":[0.0002093069,0.0005901241,0.0008903433,0.0003640878,0.001386765,0.0004428101,0.0004333412,0.002375892,0.002005008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005689969,"about_ca_system_score_gemma":0.0003609056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001367514,"about_ca_topic_score_gemma":0.001287363,"domain_scores_codex":[0.9994264,0.0000774084,0.00008075644,0.0001651789,0.0001205021,0.000129808],"domain_scores_gemma":[0.9991909,0.0001387724,0.0002941549,0.00008614556,0.00002931126,0.0002607291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003594204,0.0001286348,0.0001812719,0.00004219887,0.0000203582,0.0002006881,0.00003142031,0.000106297,0.9976094,0.0002758288,0.0001709866,0.0008735728],"study_design_scores_gemma":[0.0001679531,0.0004858613,0.005010785,0.00002630228,0.00005433431,0.0007889227,0.00008961008,0.00114027,0.9882685,0.0001313455,0.003817605,0.00001840498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793068,0.001316665,0.006491386,0.00120175,0.0003100706,0.0001034881,0.006423777,0.0008871526,0.003958855],"genre_scores_gemma":[0.9640048,0.001272374,0.004392207,0.0006851902,0.0001010195,0.0002357827,0.003299206,0.0008046544,0.02520483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007481625,"threshold_uncertainty_score":0.02502859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01387472992862667,"score_gpt":0.2302160798784903,"score_spread":0.2163413499498636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}