{"id":"W3200856768","doi":"10.1242/dev.199732","title":"YAP establishes epiblast responsiveness to inductive signals for germ cell fate","year":2021,"lang":"en","type":"article","venue":"Development","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Max-Planck-Gesellschaft; Uehara Memorial Foundation","keywords":"Epiblast; Biology; Wnt signaling pathway; Cell biology; Germ layer; Germ cell; Germ line development; Cell fate determination; Cellular differentiation; Induced pluripotent stem cell; Stem cell; Embryonic Induction; Signal transduction; Embryonic stem cell; Genetics; Gastrulation; Embryo; Mesoderm; Embryogenesis; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001167372,0.0002928271,0.0001437654,0.0003060017,0.0001682751,0.000237419,0.0001817958,0.0001977678,0.001313753],"category_scores_gemma":[0.0001134383,0.0001641978,0.0001558548,0.00007682514,0.0002498468,0.0001960357,0.0004474873,0.0004836148,0.0003965491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001763309,"about_ca_system_score_gemma":0.0001890219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003804938,"about_ca_topic_score_gemma":0.0006829313,"domain_scores_codex":[0.9999026,0.00001674144,0.000007914025,0.00001975813,0.00003273647,0.0000202646],"domain_scores_gemma":[0.9999057,0.00001487395,0.00002663806,0.000009900347,0.00001219756,0.00003080007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001655327,0.000002170951,0.000136657,0.000007577948,9.381593e-7,0.00003618493,0.000006964375,0.00001112482,0.9993449,0.00007040501,0.000005239478,0.000361203],"study_design_scores_gemma":[0.000004340005,0.00004460679,0.005392963,0.000003416315,0.00000574869,0.0002030428,0.00002264599,0.0004334963,0.9924057,0.00003242849,0.001449111,0.00000236557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991462,0.0005132236,0.005451792,0.00004577856,0.0000101383,0.0000225677,0.0002603156,0.00006991922,0.002164319],"genre_scores_gemma":[0.993548,0.0004419983,0.002920678,0.00002572587,0.000006062171,0.00002106519,0.0004278387,0.00003078096,0.00257785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001313753,"threshold_uncertainty_score":0.004394889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.021601129439851,"score_gpt":0.2624194943314926,"score_spread":0.2408183648916416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}