{"id":"W3200856768","doi":"10.1242/dev.199732","title":"YAP establishes epiblast responsiveness to inductive signals for germ cell fate","year":2021,"lang":"en","type":"article","venue":"Development","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Max-Planck-Gesellschaft; Uehara Memorial Foundation","keywords":"Epiblast; Biology; Wnt signaling pathway; Cell biology; Germ layer; Germ cell; Germ line development; Cell fate determination; Cellular differentiation; Induced pluripotent stem cell; Stem cell; Embryonic Induction; Signal transduction; Embryonic stem cell; Genetics; Gastrulation; Embryo; Mesoderm; Embryogenesis; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003365524,0.000175784,0.0001768313,0.00006096406,0.0001416544,0.00005036309,0.000148838,0.0001261465,0.00003197201],"category_scores_gemma":[0.0002200744,0.0001765567,0.00006950782,0.0001591797,0.00002077457,0.000003746913,0.0001340311,0.0000607054,0.00004269976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003538725,"about_ca_system_score_gemma":0.0007418377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003827083,"about_ca_topic_score_gemma":0.00002220916,"domain_scores_codex":[0.9987299,0.00007785788,0.0002448545,0.0004804205,0.0001444082,0.0003225972],"domain_scores_gemma":[0.9991468,0.00004442574,0.00006414566,0.0002412731,0.0003582994,0.0001450648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001330535,0.00006787417,0.0002532825,0.00002929942,0.00004316088,0.0000147702,0.0006424144,0.0001662316,0.9910699,0.00001581688,0.000863122,0.006701139],"study_design_scores_gemma":[0.0002620726,0.0000880318,0.0009061869,0.00002489973,0.00000607521,0.000004111052,0.0002512267,0.00000279315,0.7404466,0.00003378041,0.2577713,0.0002029749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849352,0.0002496087,0.01337683,0.0002184892,0.0002117042,0.000273833,0.00003504338,0.00001610802,0.0006831404],"genre_scores_gemma":[0.969856,0.00001826881,0.02338227,0.0007379118,0.0001714634,0.0002079469,0.0002707877,0.00003534645,0.005319992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2569081,"threshold_uncertainty_score":0.7199774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.021601129439851,"score_gpt":0.2624194943314926,"score_spread":0.2408183648916416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}