{"id":"W3200861464","doi":"","title":"Inhibition of BCL-xL with the small molecule UBX1967 targets Col1a1-positive endothelial cells in ischemic retinopathy","year":2021,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Retinal and Optic Conditions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Medicine; Ophthalmology; VEGF receptors; Retinopathy; Cancer research; Chemistry; Pharmacology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0004922368,0.0001792698,0.0003082862,0.0001307322,0.0001842613,0.00001907224,0.0001600347,0.00008262214,0.0001304626],"category_scores_gemma":[0.0003428279,0.0001236718,0.000056282,0.001262156,0.004677102,0.0001176986,0.0001309952,0.0003545692,0.00002057671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009718558,"about_ca_system_score_gemma":0.000979581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001121994,"about_ca_topic_score_gemma":0.0000178094,"domain_scores_codex":[0.9982569,0.0001866803,0.0002910675,0.0005070766,0.0003770356,0.0003811984],"domain_scores_gemma":[0.9986976,0.0002366234,0.0001789414,0.0002177656,0.0004878873,0.0001811753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009990886,0.0001995027,0.006666687,0.00002058469,0.00001318444,0.00126283,0.001522304,0.00001062235,0.9899274,0.0001956055,0.0000426102,0.00003881513],"study_design_scores_gemma":[0.0007031499,0.001015909,0.04473589,0.000213065,0.00003770725,0.001044245,0.001154421,0.0001267012,0.9502739,0.0005454097,0.00001953083,0.0001301147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863416,0.00008123012,0.00001468849,0.001799884,0.00007401018,0.0003917377,0.00004242453,0.00001200512,0.01124241],"genre_scores_gemma":[0.9974539,0.000004590661,0.00143405,0.0005166988,0.00004014658,0.00005075695,0.00002290405,0.00001119659,0.0004657122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03965349,"threshold_uncertainty_score":0.9980316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02028337292580364,"score_gpt":0.2876066453067488,"score_spread":0.2673232723809452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}