{"id":"W3200900308","doi":"10.3390/ph14100948","title":"Deep Modeling of Regulating Effects of Small Molecules on Longevity-Associated Genes","year":2021,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Longevity; Computational biology; Biology; Gene; Medicine; Bioinformatics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001787254,0.0004104952,0.0003484434,0.0002131124,0.000115531,0.0003316272,0.0003978069,0.0004624971,0.001135973],"category_scores_gemma":[0.0003468281,0.0001689305,0.0004536212,0.0002083599,0.0002826785,0.0003006892,0.0002035909,0.0004430197,0.0001223337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000549918,"about_ca_system_score_gemma":0.0006166386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007052157,"about_ca_topic_score_gemma":0.008150437,"domain_scores_codex":[0.9999582,0.000008456474,0.000001663374,0.00001251696,0.000008802068,0.00001039563],"domain_scores_gemma":[0.9999025,0.00005049005,0.0000154405,0.000005098687,0.00001825502,0.000008219534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00003123958,0.00001832409,0.0007565086,0.00002699178,0.00001671295,0.00003125004,0.00000813492,0.9846039,0.006703246,0.002428211,0.0002005988,0.005174923],"study_design_scores_gemma":[0.00000164691,0.000006309436,0.0001210069,7.680597e-7,0.000003333533,0.00000268293,9.645881e-7,0.998619,0.000480275,0.0006652835,0.00009788247,8.53733e-7],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.534416,0.001698008,0.4526832,0.0007677084,0.00009057784,0.00004514866,0.001230048,0.0006618394,0.008407443],"genre_scores_gemma":[0.9772868,0.0006445701,0.01666622,0.0001358593,0.00001808371,0.00006712278,0.0003459245,0.00002486925,0.004810644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007052157,"threshold_uncertainty_score":0.01402223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02728138707680158,"score_gpt":0.2947435606114031,"score_spread":0.2674621735346016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}