{"id":"W3200928356","doi":"10.1126/science.abg5159","title":"Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice","year":2021,"lang":"en","type":"article","venue":"Science","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":299,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"","keywords":"Reprogramming; KLF4; Biology; Cell biology; SOX2; Regeneration (biology); Cell; Embryonic stem cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003822523,0.00004340281,0.00007120779,0.0000614062,0.00005156027,0.00003018668,0.0001184857,0.00002005602,0.000003434339],"category_scores_gemma":[0.0004144727,0.00004579695,0.00003086856,0.0006992805,0.0001292939,0.000008549925,0.0002071724,0.00003815795,0.00000516426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001784842,"about_ca_system_score_gemma":0.000372532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004925277,"about_ca_topic_score_gemma":0.0002626102,"domain_scores_codex":[0.9991325,0.00003958015,0.00009718584,0.0003218201,0.0002077554,0.0002011745],"domain_scores_gemma":[0.9995114,0.000008590614,0.00001282985,0.0002338393,0.000165563,0.00006774304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001104164,0.00001247418,0.004406936,0.000008886289,0.000001766268,0.000005156436,0.00008306133,0.0001009675,0.9876267,0.000004799314,0.00002790441,0.007710266],"study_design_scores_gemma":[0.00008174564,0.00009255204,0.007389819,0.00001176183,8.561006e-7,0.00001348251,0.00008479555,0.0000927607,0.9886417,0.00001624731,0.003521796,0.00005252565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998418,0.000596341,0.0002500183,0.0001890026,0.00005073027,0.0001059838,0.000003056225,0.000002836317,0.000384079],"genre_scores_gemma":[0.9950922,0.00002475535,0.004248207,0.00003932586,0.0000208261,0.00000676292,0.000004154281,0.000003399107,0.0005604089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00765774,"threshold_uncertainty_score":0.1867546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01420427165020074,"score_gpt":0.3057042621507161,"score_spread":0.2914999905005153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}