{"id":"W3200931843","doi":"10.1016/j.cell.2021.08.021","title":"Open-state structure and pore gating mechanism of the cardiac sodium channel","year":2021,"lang":"en","type":"article","venue":"Cell","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":116,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Hospital for Sick Children; National Institute of Neurological Disorders and Stroke; Western Canada Research Grid; Compute Canada; University of Washington; U.S. Department of Agriculture; Howard Hughes Medical Institute","keywords":"Biology; Gating; Sodium channel; Mechanism (biology); Biophysics; Sodium; Cell biology; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001544784,0.00009543174,0.0001731798,0.0001055418,0.0003959876,0.0004789447,0.0003919797,0.0003716601,0.0008429592],"category_scores_gemma":[0.0003782654,0.0001066409,0.0001381821,0.00009324858,0.0004689043,0.0006529556,0.0001742874,0.0005406402,0.0001384548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002787851,"about_ca_system_score_gemma":0.0002179077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003642295,"about_ca_topic_score_gemma":0.0004090415,"domain_scores_codex":[0.9999449,0.00000991439,0.000003862068,0.00001787532,0.00001443792,0.000009000266],"domain_scores_gemma":[0.9998387,0.00006209951,0.000028877,0.00002000207,0.00002236294,0.00002796627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000487046,0.00009818518,0.001596639,0.00007182264,0.00001092705,0.0002993287,0.000343615,0.00206101,0.9671277,0.02290692,0.0001795254,0.004817318],"study_design_scores_gemma":[0.0001798387,0.001355284,0.04999305,0.00004882002,0.00009226955,0.001811635,0.0007343425,0.1117559,0.7867392,0.04076909,0.006329766,0.0001907861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951929,0.0002897053,0.003424329,0.0001007923,0.00001458051,0.000003700305,0.00004366893,0.00002029985,0.0009100155],"genre_scores_gemma":[0.9988492,0.0001482347,0.0006115583,0.00002493408,0.00000712132,0.000003120622,0.00009664461,0.000006124698,0.0002530408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008429592,"threshold_uncertainty_score":0.002819955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0086834884049253,"score_gpt":0.2144660701516543,"score_spread":0.205782581746729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}