{"id":"W3200931843","doi":"10.1016/j.cell.2021.08.021","title":"Open-state structure and pore gating mechanism of the cardiac sodium channel","year":2021,"lang":"en","type":"article","venue":"Cell","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":116,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Hospital for Sick Children; National Institute of Neurological Disorders and Stroke; Western Canada Research Grid; Compute Canada; University of Washington; U.S. Department of Agriculture; Howard Hughes Medical Institute","keywords":"Biology; Gating; Sodium channel; Mechanism (biology); Biophysics; Sodium; Cell biology; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005329787,0.00005543175,0.0000660861,0.000006249303,0.00005979276,0.00001786873,0.00007797511,0.00005822611,0.00001820931],"category_scores_gemma":[0.00001499605,0.00004226278,0.00003491211,0.00004427123,0.00002071348,0.000002118573,0.0002021778,0.00003847719,4.690667e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002728849,"about_ca_system_score_gemma":0.0000362107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000501671,"about_ca_topic_score_gemma":0.00000408898,"domain_scores_codex":[0.9996234,0.00003464237,0.00007728335,0.0001420187,0.00005255018,0.00007015846],"domain_scores_gemma":[0.9996953,0.000002760678,0.00005374603,0.0001545395,0.00007061269,0.00002303402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009315962,0.000007691781,0.00009869203,0.00001973704,0.00001009549,5.071996e-7,0.0001186943,0.00005539626,0.9984876,0.0001751053,0.000678446,0.0003387462],"study_design_scores_gemma":[0.0001986833,0.00002003627,0.0005407947,0.000005514483,0.000006596068,0.000003859962,0.0001620417,0.0002273934,0.9933041,0.0007595812,0.004717547,0.00005389569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953424,0.0003662271,0.0006885978,0.0002085186,0.0008095086,0.0001251924,0.00003829424,0.000003138771,0.00241809],"genre_scores_gemma":[0.9951912,0.00004659907,0.0001348666,0.0001560341,0.0001182375,0.000002043854,0.00007617181,0.000007641547,0.004267201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005183516,"threshold_uncertainty_score":0.1723426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0086834884049253,"score_gpt":0.2144660701516543,"score_spread":0.205782581746729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}