{"id":"W3200939841","doi":"10.1002/dad2.12231","title":"Effect of <i>APOE</i> ε4 allele on levels of apolipoproteins E, J, and D, and redox signature in circulating extracellular vesicles from cognitively impaired with no dementia participants converted to Alzheimer's disease","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut National de la Recherche Scientifique","funders":"","keywords":"Apolipoprotein E; Oxidative stress; Dementia; Alzheimer's disease; Internal medicine; Allele; Antioxidant; Apolipoprotein B; Endocrinology; Pathological; Psychology; Degenerative disease; Medicine; Biochemistry; Cholesterol; Disease; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003000969,0.0003094519,0.0002599177,0.0003280096,0.0002268406,0.0005622893,0.000129553,0.0002693158,0.001324088],"category_scores_gemma":[0.0008212521,0.0001465187,0.0002593684,0.0001672218,0.0002184794,0.0001828554,0.0002427986,0.0003300998,0.0001369586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001615227,"about_ca_system_score_gemma":0.0001273674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003142757,"about_ca_topic_score_gemma":0.002244378,"domain_scores_codex":[0.9998466,0.00003963528,0.0000143262,0.00004655761,0.00002067929,0.00003231993],"domain_scores_gemma":[0.9996505,0.00009271088,0.00008730104,0.00003085835,0.00005628983,0.00008230949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0305376,0.001128516,0.8357015,0.00007390189,0.0005166515,0.0005189517,0.0007334935,0.0001139478,0.1191932,0.0001080905,0.0002481917,0.01112595],"study_design_scores_gemma":[0.00004452383,0.001788562,0.9894782,0.000007574499,0.0001818287,0.000254671,0.0003161113,0.0002742227,0.007316899,0.00006236002,0.0002670742,0.000008033845],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997359,0.00005984538,0.00002627308,0.000007160706,0.000003522793,0.000002409766,0.00004349744,0.000001041701,0.0001204069],"genre_scores_gemma":[0.9994141,0.00002474952,0.00004710117,0.00001476654,0.00000203986,0.000003249042,0.00007752381,0.000001191118,0.0004153464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003142757,"threshold_uncertainty_score":0.006248891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0204084232151752,"score_gpt":0.2953587243650093,"score_spread":0.2749503011498341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}