{"id":"W3200943028","doi":"10.2174/0929867328666210910154330","title":"Therapeutic Targeting of Inflammatory Pathways with Emphasis onNLRP3 Inflammasomes by Natural Products: A Novel Approach forthe Treatment of Inflammatory Eye Diseases","year":2021,"lang":"en","type":"review","venue":"Current Medicinal Chemistry","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Inflammasome; Medicine; Disease; Bioinformatics; Inflammation; Immunology; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002008919,0.001011821,0.002054874,0.00009059408,0.0001003377,0.00002141985,0.0005640091,0.0004329662,0.00001992828],"category_scores_gemma":[0.0001728713,0.0007315295,0.0007524368,0.0003214256,0.0005340173,0.00001636773,0.0001657977,0.0003906135,0.000001108769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001196299,"about_ca_system_score_gemma":0.001652512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003244086,"about_ca_topic_score_gemma":5.932812e-7,"domain_scores_codex":[0.99639,0.000113147,0.00134275,0.0009878043,0.0005847463,0.0005815463],"domain_scores_gemma":[0.9970247,0.00005099799,0.001330821,0.001022122,0.0004172967,0.0001540811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003210379,0.002202952,0.001403392,0.09272932,0.003657359,0.000022845,0.00059119,0.000007833899,0.1639003,0.00001803517,0.0008923984,0.7342533],"study_design_scores_gemma":[0.001981634,0.0003847469,0.000026657,0.007208814,0.002169897,0.00004724137,0.0007860097,0.000005827073,0.09716771,0.000001629634,0.8892212,0.0009986614],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03142919,0.9669431,0.00005001052,0.000006895047,0.0002677077,0.0008603171,0.0003030858,0.00002479199,0.0001149031],"genre_scores_gemma":[0.011005,0.9791776,0.00007758899,0.000005838715,0.0006118371,0.0003849967,0.008400933,0.0001264337,0.0002097623],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8883288,"threshold_uncertainty_score":0.9995136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02009120838580839,"score_gpt":0.2801669505509754,"score_spread":0.260075742165167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}