{"id":"W3200943028","doi":"10.2174/0929867328666210910154330","title":"Therapeutic Targeting of Inflammatory Pathways with Emphasis onNLRP3 Inflammasomes by Natural Products: A Novel Approach forthe Treatment of Inflammatory Eye Diseases","year":2021,"lang":"en","type":"review","venue":"Current Medicinal Chemistry","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Inflammasome; Medicine; Disease; Bioinformatics; Inflammation; Immunology; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002603313,0.0006730757,0.0008474486,0.0016082,0.0002217318,0.0005663189,0.000496651,0.000680969,0.003008568],"category_scores_gemma":[0.0002235321,0.0001721129,0.0005010696,0.001060793,0.0003262105,0.0008399988,0.0004721086,0.001549212,0.001055403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003048957,"about_ca_system_score_gemma":0.0005161276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003444267,"about_ca_topic_score_gemma":0.0008173201,"domain_scores_codex":[0.9998851,0.00001854515,0.00001413197,0.00002124185,0.00004561747,0.00001526805],"domain_scores_gemma":[0.9999199,0.00002845458,0.00001586219,0.000004049022,0.00002195644,0.000009830415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001500213,0.0002136264,0.0001983618,0.02360523,0.0001437057,0.0004677141,0.0000905301,0.0005653358,0.02406492,0.005377686,0.01778197,0.9273409],"study_design_scores_gemma":[0.00004846492,0.0004200188,0.00156856,0.002456826,0.0001667062,0.002292292,0.00007487019,0.0002643133,0.005989802,0.002833196,0.983852,0.00003306389],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005697616,0.9971241,0.0004338436,0.0002599706,0.000250658,0.00001037958,0.00002512361,0.0000144569,0.001311642],"genre_scores_gemma":[0.002512921,0.9957852,0.0004411201,0.000204452,0.0001511721,0.00001013028,0.00004575806,0.000002061271,0.0008472091],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003008568,"threshold_uncertainty_score":0.01006466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02009120838580839,"score_gpt":0.2801669505509754,"score_spread":0.260075742165167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}