{"id":"W3200952502","doi":"10.21203/rs.3.rs-876507/v1","title":"Pharmacological Rescue with SR8278, A Circadian Nuclear Receptor REV-ERBα Antagonist as a Therapy for Mood Disorders in Parkinson’s Disease","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Ministry of Science and ICT, South Korea; Daegu Gyeongbuk Institute of Science and Technology; National Science Foundation","keywords":"Disease; Circadian rhythm; Medicine; Neuroscience; Parkinson's disease; Mood disorders; Antagonist; Mood; Pharmacology; Receptor; Bioinformatics; Psychiatry; Psychology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001048637,0.0002976214,0.0004866145,0.0002018964,0.000110927,0.0001368475,0.0002890627,0.0002237538,0.0009524028],"category_scores_gemma":[0.00006719476,0.00006911004,0.0002994224,0.0001232222,0.0001151501,0.0001250447,0.00009330613,0.0004863543,0.0002894974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001044433,"about_ca_system_score_gemma":0.0001608165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000295932,"about_ca_topic_score_gemma":0.0009068184,"domain_scores_codex":[0.9999517,0.000009879733,0.000007359927,0.000008895954,0.000009938104,0.00001221745],"domain_scores_gemma":[0.999966,0.000002778154,0.00001109664,0.000004107687,0.000005858133,0.00001020334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002488795,0.0007762415,0.0005832366,0.0004967971,0.000103924,0.0003201822,0.00004654154,0.0001828478,0.9562684,0.0001716324,0.0006553945,0.03790604],"study_design_scores_gemma":[0.007129572,0.05187063,0.06771979,0.0002752945,0.0009232442,0.004828549,0.0003026573,0.004388602,0.819076,0.0004863107,0.04292239,0.0000770281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787951,0.01689379,0.001071422,0.0002527524,0.0001512735,0.00008075841,0.0004118633,0.0001617915,0.002181333],"genre_scores_gemma":[0.9869241,0.008483276,0.001689943,0.0001435155,0.00005711207,0.00009178304,0.000641631,0.00001494224,0.001953762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009524028,"threshold_uncertainty_score":0.003186047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05955413834407264,"score_gpt":0.3725510153891148,"score_spread":0.3129968770450422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}