{"id":"W3200956026","doi":"10.26434/chemrxiv.14390672.v1","title":"Polycomb Paralog Chromodomain Inhibitors Active Against Both CBX6 and CBX8","year":2021,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Chromodomain; PRC2; Polycomb-group proteins; Chromatin; Histone H3; Biology; Transcription factor; Genetics; Gene; Cell biology; Chemistry; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001195961,0.0003816215,0.0003500053,0.00006499793,0.0000838257,0.00007704274,0.0001865749,0.0008935179,0.00002231973],"category_scores_gemma":[0.00005787452,0.0004275338,0.0002034453,0.0000952925,0.0001641424,0.000004871525,0.0007151942,0.0004090423,0.000004223965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001028444,"about_ca_system_score_gemma":0.000303223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004465646,"about_ca_topic_score_gemma":0.00006192351,"domain_scores_codex":[0.9982362,0.00007193369,0.0002974216,0.0009133111,0.0001696419,0.0003114275],"domain_scores_gemma":[0.9988444,0.00001218776,0.0002251791,0.0006916421,0.00008540619,0.0001411873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007863074,0.00006319463,0.0006118791,0.00012379,0.0002912639,0.00001255486,0.0001620859,0.0005547311,0.9864473,0.000009606081,0.002604032,0.009040919],"study_design_scores_gemma":[0.0006939443,0.00006385324,0.006183875,0.0001834741,0.00007969465,0.00002128891,0.0001261705,0.0001985738,0.9845774,0.0001412793,0.007121469,0.0006089894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910815,0.00600004,0.0002831865,0.0002806456,0.0007028751,0.0003380134,0.00001785905,0.00003313849,0.001262782],"genre_scores_gemma":[0.9945683,0.001783703,0.0004356512,0.0001529723,0.0009519931,0.00006435209,0.001464403,0.00006727683,0.0005113336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00843193,"threshold_uncertainty_score":0.9998177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007935516791895617,"score_gpt":0.2350584677956427,"score_spread":0.227122951003747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}