{"id":"W3200971086","doi":"10.3389/fmicb.2021.727039","title":"Dnj1 Promotes Virulence in Cryptococcus neoformans by Maintaining Robust Endoplasmic Reticulum Homeostasis Under Temperature Stress","year":2021,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft; Natural Sciences and Engineering Research Council of Canada; Canadian Institute for Advanced Research","keywords":"Virulence; Cryptococcus neoformans; Endoplasmic reticulum; Biology; Unfolded protein response; Microbiology; Chaperone (clinical); Mutant; Virulence factor; Endoplasmic-reticulum-associated protein degradation; Cryptococcosis; Cell biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009002678,0.0002556503,0.0001912844,0.0001552205,0.0001700344,0.0002261478,0.0001613748,0.0001750619,0.0005846842],"category_scores_gemma":[0.00008793831,0.00009017895,0.0001435529,0.0001209411,0.0001590896,0.00009774541,0.0001638766,0.0003824415,0.0001982558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004457242,"about_ca_system_score_gemma":0.000265315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001095598,"about_ca_topic_score_gemma":0.001752967,"domain_scores_codex":[0.9999197,0.000009539728,0.000008524731,0.00001520675,0.00002053364,0.00002651201],"domain_scores_gemma":[0.9998786,0.000008257451,0.00003850429,0.000009810558,0.00001493787,0.00004983372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008535617,0.00002546597,0.0002312935,0.00002269481,0.000001345244,0.00004418223,0.000007277727,0.00002610351,0.9991062,0.00001966923,0.00002545584,0.0004048433],"study_design_scores_gemma":[0.00002050822,0.0003683124,0.02035191,0.00001253891,0.00001501129,0.0005168274,0.00007334748,0.0009607467,0.975015,0.00004677967,0.00261306,0.000006025852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985029,0.0004517441,0.0002828771,0.00007367926,0.00001389897,0.000008557126,0.0001934406,0.00003137092,0.000441447],"genre_scores_gemma":[0.9970831,0.0003230102,0.0006786995,0.00005903956,0.000004960478,0.000009234662,0.0004088921,0.00001328082,0.00141966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001095598,"threshold_uncertainty_score":0.003233969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007849170233237538,"score_gpt":0.2278108403341911,"score_spread":0.2199616701009536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}