{"id":"W3200993708","doi":"10.1186/s11689-021-09384-z","title":"Current neurologic treatment and emerging therapies in CDKL5 deficiency disorder","year":2021,"lang":"en","type":"article","venue":"Journal of Neurodevelopmental Disorders","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; International Foundation for CDKL5 Research","keywords":"Medicine; Movement disorders; Population; Pediatrics; Epilepsy; Neurology; Lamotrigine; Vagus nerve stimulation; Psychiatry; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008161589,0.0002079533,0.0003204767,0.0006613025,0.000347551,0.0006817995,0.0004213216,0.0006069706,0.001821325],"category_scores_gemma":[0.001439181,0.00006212782,0.0003321179,0.0005993798,0.0005016924,0.0007364812,0.0003566111,0.0007988437,0.0002756465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00161791,"about_ca_system_score_gemma":0.000840181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001459107,"about_ca_topic_score_gemma":0.005180639,"domain_scores_codex":[0.9995611,0.0001300164,0.0001037753,0.00005313358,0.00009657377,0.00005537077],"domain_scores_gemma":[0.9991523,0.0003529929,0.0002875247,0.00002201239,0.00009970637,0.00008542297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008813891,0.0004628824,0.0612002,0.003166047,0.0001607181,0.006151372,0.0005557216,0.0009178153,0.003996602,0.006526605,0.01364041,0.9023404],"study_design_scores_gemma":[0.0006814045,0.00461046,0.2283824,0.01280634,0.001272248,0.1186028,0.005195463,0.004455796,0.009700565,0.01476558,0.5994108,0.0001161402],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1413376,0.8080469,0.001174799,0.02705692,0.0005279619,0.00003978694,0.0002779573,0.00004845075,0.02148958],"genre_scores_gemma":[0.6363207,0.3487116,0.003208135,0.006934033,0.001460419,0.00007147797,0.0004851684,0.00001635198,0.002792179],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001821325,"threshold_uncertainty_score":0.01173878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009993332758210927,"score_gpt":0.247891202916827,"score_spread":0.2378978701586161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}