{"id":"W3201000277","doi":"10.1016/j.isci.2021.103295","title":"Effective chimeric antigen receptor T cells against SARS-CoV-2","year":2021,"lang":"en","type":"article","venue":"iScience","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research","keywords":"Perforin; Chimeric antigen receptor; Granzyme B; Antigen; Cytolysis; Biology; Granzyme; Virology; Cell biology; Receptor; Cytotoxic T cell; Chemistry; Molecular biology; Immune system; In vitro; T cell; Immunology; CD8; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002387192,0.0004262083,0.0002725153,0.0002021466,0.0001102167,0.0003216392,0.0001839211,0.0004388962,0.002682672],"category_scores_gemma":[0.0001458213,0.0001370761,0.0002396814,0.0000871186,0.00018714,0.0002206099,0.0001616318,0.0009212436,0.0005464517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002485595,"about_ca_system_score_gemma":0.000367121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003087614,"about_ca_topic_score_gemma":0.0005139168,"domain_scores_codex":[0.9998001,0.00004046235,0.0000104103,0.00003290356,0.00004358141,0.00007254094],"domain_scores_gemma":[0.9999478,0.00001165943,0.00001185215,0.000006553699,0.000007731813,0.00001449474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000327567,0.0002088704,0.0001170004,0.00004672656,0.00001124523,0.00006456732,0.00004593992,0.0007632853,0.9911401,0.0008348853,0.0006746065,0.005765221],"study_design_scores_gemma":[0.0007493753,0.00324415,0.002027421,0.00002453608,0.00005895062,0.0006208342,0.00004934042,0.005353075,0.9642016,0.0004579035,0.02319901,0.00001368563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812889,0.001876478,0.008837864,0.0004279815,0.00012708,0.0001302812,0.0006342977,0.0003771632,0.006299971],"genre_scores_gemma":[0.99038,0.0006295223,0.0023241,0.0001348596,0.00003513833,0.00008176298,0.0006729716,0.00002611079,0.005715465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002682672,"threshold_uncertainty_score":0.008974493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02996694581285369,"score_gpt":0.3397855715107883,"score_spread":0.3098186256979346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}