{"id":"W3201000277","doi":"10.1016/j.isci.2021.103295","title":"Effective chimeric antigen receptor T cells against SARS-CoV-2","year":2021,"lang":"en","type":"article","venue":"iScience","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research","keywords":"Perforin; Chimeric antigen receptor; Granzyme B; Antigen; Cytolysis; Biology; Granzyme; Virology; Cell biology; Receptor; Cytotoxic T cell; Chemistry; Molecular biology; Immune system; In vitro; T cell; Immunology; CD8; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003844322,0.0001178375,0.0002166379,0.00009025719,0.0001189727,0.00005049611,0.0001902864,0.00005259591,0.0008287027],"category_scores_gemma":[0.0001690439,0.0001010099,0.00009508853,0.001043521,0.0002750138,0.0001004742,0.0001171812,0.0002268723,0.0007959605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001111661,"about_ca_system_score_gemma":0.0002904174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003242096,"about_ca_topic_score_gemma":0.00000840195,"domain_scores_codex":[0.9983624,0.00009553071,0.0001344627,0.0004539613,0.0005485516,0.000405101],"domain_scores_gemma":[0.9991409,0.0001108573,0.00003496248,0.0004383657,0.0001653034,0.0001095679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003359884,0.00008464481,0.001099534,0.0000168904,0.00001407975,0.00009283814,0.0003382213,0.000002084607,0.9163522,0.0000115031,0.00265468,0.07929979],"study_design_scores_gemma":[0.0004225963,0.0001419022,0.005843421,0.00004538652,0.00000506231,0.00002647174,0.00008262059,0.0002053377,0.9038219,0.00001573001,0.0892868,0.0001027042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9640681,0.0006702805,0.0001798097,0.0006506511,0.0004217891,0.0003924295,0.000005364317,0.00005367527,0.0335579],"genre_scores_gemma":[0.9846522,0.0005119877,0.001471809,0.001826725,0.0002405095,0.00002957658,0.000008906371,0.00002528054,0.01123301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08663213,"threshold_uncertainty_score":0.9999821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02996694581285369,"score_gpt":0.3397855715107883,"score_spread":0.3098186256979346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}