{"id":"W3201013983","doi":"10.1016/s1470-2045(21)00375-2","title":"Long-term clinical outcomes of tisagenlecleucel in patients with relapsed or refractory aggressive B-cell lymphomas (JULIET): a multicentre, open-label, single-arm, phase 2 study","year":2021,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":561,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont; McMaster University","funders":"Novartis Pharmaceuticals Corporation","keywords":"Medicine; Clinical endpoint; Internal medicine; Refractory (planetary science); Cytokine release syndrome; Oncology; Hematopoietic stem cell transplantation; Chimeric antigen receptor; Cohort; Transplantation; Clinical trial; Immunotherapy; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001384817,0.001103203,0.001898963,0.000344938,0.0003494171,0.001317844,0.0006822866,0.001352865,0.001773809],"category_scores_gemma":[0.000795852,0.0003290438,0.001533427,0.0003285827,0.000790326,0.0009291578,0.0004106947,0.0021833,0.0006469082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006552793,"about_ca_system_score_gemma":0.000744865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006201947,"about_ca_topic_score_gemma":0.001300397,"domain_scores_codex":[0.9995713,0.0001631793,0.00002006723,0.00007013123,0.00004704739,0.0001283362],"domain_scores_gemma":[0.9992084,0.0001330532,0.0001746627,0.00008073412,0.00004612611,0.0003571013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.842065,0.04095067,0.01378863,0.0006924144,0.002637386,0.0002062283,0.0002733199,0.001546715,0.01740957,0.0001976345,0.00223641,0.0779961],"study_design_scores_gemma":[0.4275003,0.5158517,0.04836385,0.00006888903,0.001729507,0.0002402611,0.0001643835,0.001262366,0.001845235,0.0002905765,0.002617574,0.00006529762],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978138,0.001028999,0.00009132609,0.0001187243,0.00004101679,0.0001698096,0.0002868352,0.0000214486,0.0004280244],"genre_scores_gemma":[0.9940514,0.001122677,0.0004010923,0.0005440929,0.0001516803,0.0006143461,0.001251419,0.0000220552,0.001841298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001898963,"threshold_uncertainty_score":0.007323682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1492125776892486,"score_gpt":0.4590593045005727,"score_spread":0.3098467268113241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}