{"id":"W3201013983","doi":"10.1016/s1470-2045(21)00375-2","title":"Long-term clinical outcomes of tisagenlecleucel in patients with relapsed or refractory aggressive B-cell lymphomas (JULIET): a multicentre, open-label, single-arm, phase 2 study","year":2021,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":561,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont; McMaster University","funders":"Novartis Pharmaceuticals Corporation","keywords":"Medicine; Clinical endpoint; Internal medicine; Refractory (planetary science); Cytokine release syndrome; Oncology; Hematopoietic stem cell transplantation; Chimeric antigen receptor; Cohort; Transplantation; Clinical trial; Immunotherapy; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001293543,0.0002696253,0.001631843,0.000106055,0.00007406018,0.00003009968,0.000648835,0.0002193903,0.001945349],"category_scores_gemma":[0.001001262,0.0001586251,0.00007877134,0.0004687956,0.0003549483,0.00009412426,0.0005129078,0.0007281473,0.00004663755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004286454,"about_ca_system_score_gemma":0.001029442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007880131,"about_ca_topic_score_gemma":0.000992425,"domain_scores_codex":[0.9957583,0.001626735,0.0008720403,0.000587235,0.0005590272,0.0005966816],"domain_scores_gemma":[0.9957576,0.001878999,0.0006230221,0.001173286,0.0003777102,0.0001894112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04795652,0.09310974,0.7945369,0.0000778922,0.0005311684,0.003028312,0.001645056,8.913502e-7,0.001922937,0.000002654581,0.0006999822,0.05648797],"study_design_scores_gemma":[0.24618,0.03607895,0.7128395,0.0001552739,0.0002901174,0.00003778403,0.000648556,0.00002352672,0.0008902606,0.000006918991,0.002641767,0.0002072909],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925367,0.0002697322,0.000003830933,0.000801186,0.0003061876,0.002553468,0.00002689681,0.00002897565,0.003473032],"genre_scores_gemma":[0.9915817,0.0002729837,0.000530128,0.001358816,0.0001711206,0.00009773017,0.00006430573,0.0000589181,0.005864256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1982235,"threshold_uncertainty_score":0.998967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1492125776892486,"score_gpt":0.4590593045005727,"score_spread":0.3098467268113241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}