{"id":"W3201015904","doi":"10.1101/2021.09.10.459444","title":"Transplantation of bacteriophages from ulcerative colitis patients shifts the gut bacteriome and exacerbates severity of DSS-colitis","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; McGill University","funders":"Canadian Institutes of Health Research; Kenneth Rainin Foundation; McGill University","keywords":"Human virome; Colitis; Inflammatory bowel disease; Gut flora; Ulcerative colitis; Microbiome; Immunology; Dysbiosis; Biology; Metagenomics; Microbiology; Disease; Medicine; Pathology; Bioinformatics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001648383,0.0004328425,0.000426459,0.0003304459,0.0001792452,0.0003365193,0.0001178046,0.0003933451,0.001784021],"category_scores_gemma":[0.0001585564,0.0001408557,0.0003487078,0.0001528583,0.0002637669,0.0001833141,0.0002885091,0.001251502,0.0002098967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001285466,"about_ca_system_score_gemma":0.0001621481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002404841,"about_ca_topic_score_gemma":0.0003004035,"domain_scores_codex":[0.9997572,0.00003919947,0.000024721,0.0000610799,0.00004589013,0.0000719288],"domain_scores_gemma":[0.9997976,0.00002445729,0.0000473414,0.00001617339,0.0000133649,0.0001010839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008051456,0.0002691941,0.001031149,0.00004105563,0.00001207051,0.00004554849,0.00002258627,0.00003245767,0.9961979,0.00001857145,0.00003708197,0.001487244],"study_design_scores_gemma":[0.0002150522,0.02750967,0.1227078,0.00005801856,0.0001406945,0.001396179,0.0004356476,0.001954535,0.8424907,0.0001476998,0.002913469,0.00003049207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988809,0.0003145356,0.0003903304,0.0000415184,0.00003315169,0.00001626928,0.0001227356,0.0000226389,0.0001779506],"genre_scores_gemma":[0.9979163,0.0002806535,0.0006153752,0.00009860849,0.00001821761,0.00002605992,0.0003098751,0.000009900157,0.0007251214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001784021,"threshold_uncertainty_score":0.005968153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007232329175266098,"score_gpt":0.2000754794374123,"score_spread":0.1928431502621462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}