{"id":"W3201017497","doi":"10.1182/bloodadvances.2021004451","title":"Antigen-specific immunotherapy with apitopes suppresses generation of FVIII inhibitor antibodies in HLA-transgenic mice","year":2021,"lang":"en","type":"article","venue":"Blood Advances","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University","keywords":"Immunology; Immunotherapy; Epitope; Antigen; Immune tolerance; Antibody; Human leukocyte antigen; Immune system; T cell; Medicine; Virology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001011839,0.0001815464,0.0004133226,0.0001235611,0.00007760714,0.00002412639,0.0001002143,0.00005924218,0.0001940889],"category_scores_gemma":[0.00001826041,0.0001338118,0.0000878802,0.0003536645,0.0001842868,0.0002108646,0.00002677379,0.0001711837,0.000007324971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001022735,"about_ca_system_score_gemma":0.0001376558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006639489,"about_ca_topic_score_gemma":0.0003422596,"domain_scores_codex":[0.9985542,0.00006920096,0.0003467836,0.0003332522,0.0004074255,0.0002891291],"domain_scores_gemma":[0.9993153,0.00009444149,0.00007630252,0.0002174695,0.0002330378,0.00006343872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005618673,0.0005294129,0.109854,0.0002117182,0.0001245528,0.0001198506,0.0003976516,0.00004085246,0.8803564,0.0003942263,0.0001377833,0.007271726],"study_design_scores_gemma":[0.001883167,0.0003808893,0.05025664,0.0002735712,0.00001384359,0.00009528326,0.000260539,0.00001546539,0.8832445,0.00006657462,0.063345,0.0001645488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9002777,0.09752626,0.00006037849,0.000789062,0.000158511,0.0002144167,0.00002778899,0.00001858888,0.0009272471],"genre_scores_gemma":[0.8908778,0.1030575,0.004621677,0.00009540685,0.0004200921,0.00001671866,0.00008298409,0.00002235641,0.0008054051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06320722,"threshold_uncertainty_score":0.5456687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02804752921840672,"score_gpt":0.2964604726467773,"score_spread":0.2684129434283706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}