{"id":"W3201018429","doi":"10.3390/curroncol28050304","title":"Management of Pyrexia Associated with the Combination of Dabrafenib and Trametinib: Canadian Consensus Statements","year":2021,"lang":"en","type":"article","venue":"Current Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Ottawa; University of British Columbia; Health Sciences Centre; Credit Valley Hospital; Université Laval; Ottawa Hospital; Princess Margaret Cancer Centre; McGill University; Sunnybrook Health Science Centre","funders":"Novartis Pharmaceuticals Canada","keywords":"Dabrafenib; Trametinib; Medicine; Discontinuation; Melanoma; Delphi method; Intensive care medicine; Oncology; Internal medicine; Vemurafenib; Metastatic melanoma; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05943888,0.0010765,0.001036193,0.00430221,0.005836565,0.002928456,0.004399159,0.005626705,0.002811159],"category_scores_gemma":[0.08121078,0.0006845933,0.002157694,0.003040582,0.003072313,0.001846717,0.004971325,0.005428967,0.0008543823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.03832453,"about_ca_system_score_gemma":0.2050111,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.4067884,"about_ca_topic_score_gemma":0.4880179,"domain_scores_codex":[0.9662469,0.01164136,0.006250248,0.001143248,0.01115537,0.003562935],"domain_scores_gemma":[0.8804224,0.01258937,0.005507729,0.001242012,0.08974683,0.01049169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002663286,0.0001686575,0.008464059,0.007130593,0.0002299177,0.002931234,0.01780524,0.003172655,0.004098078,0.01710145,0.6784939,0.2601379],"study_design_scores_gemma":[0.0001148594,0.0001293223,0.007775231,0.00897162,0.0001410996,0.001853656,0.008991437,0.001722446,0.001019026,0.009057965,0.9599391,0.0002843567],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.02589992,0.03311412,0.0287108,0.8113593,0.01391967,0.01112442,0.003210241,0.0002858837,0.07237565],"genre_scores_gemma":[0.501608,0.06625714,0.2580883,0.1107393,0.004584239,0.009135634,0.007337202,0.0002660985,0.04198407],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.5932117,"threshold_uncertainty_score":0.8088412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04810613995351185,"score_gpt":0.3433593410423441,"score_spread":0.2952532010888322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}