{"id":"W3201069928","doi":"10.1016/j.jneuroim.2021.577715","title":"Pharmacodynamic biomarkers of long-term interferon beta-1a therapy in REFLEX and REFLEXION","year":2021,"lang":"en","type":"article","venue":"Journal of Neuroimmunology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"EMD Serono; Alexion Pharmaceuticals; Teva Pharmaceutical Industries; Atara Biotherapeutics; Biogen; Celgene; Merck KGaA; Sanofi","keywords":"Neopterin; Medicine; Pharmacodynamics; Cohort; Downregulation and upregulation; Internal medicine; Reflex; Post-hoc analysis; Interferon; Interferon α; Oncology; Gastroenterology; Alpha interferon; Immunology; Pharmacokinetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001059222,0.0004436934,0.000884065,0.0003575207,0.0001682289,0.0009016383,0.0001905975,0.000567409,0.000990124],"category_scores_gemma":[0.004050046,0.0001358996,0.0003438975,0.000458447,0.0002688466,0.0004219416,0.0002675859,0.0007861644,0.0001911185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003443463,"about_ca_system_score_gemma":0.0002713307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003918832,"about_ca_topic_score_gemma":0.0002693261,"domain_scores_codex":[0.9994203,0.0002821542,0.00005888863,0.00007909382,0.0001018506,0.00005777408],"domain_scores_gemma":[0.9971129,0.001163469,0.001149558,0.0001365381,0.0001697484,0.0002678626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06944079,0.001358956,0.7513453,0.0004863206,0.002156913,0.0007808522,0.0002572512,0.001498036,0.06022363,0.0002723528,0.000459446,0.1117201],"study_design_scores_gemma":[0.0002979508,0.007261555,0.9845608,0.00005075039,0.0004339295,0.0006822894,0.00008777466,0.001410781,0.004490461,0.0001908318,0.0005106204,0.00002219579],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936653,0.00413582,0.0004924629,0.0001042496,0.0000330932,0.00003717513,0.0002527154,0.00002275033,0.001256439],"genre_scores_gemma":[0.9988299,0.0004605211,0.0001831025,0.00006634802,0.00003253058,0.0000262173,0.0001327999,0.000004532685,0.0002641253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001059222,"threshold_uncertainty_score":0.005601764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0822510949016751,"score_gpt":0.3962291234459074,"score_spread":0.3139780285442323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}