{"id":"W3201071899","doi":"10.1182/bloodadvances.2021004881","title":"Risk classification at diagnosis predicts post-HCT outcomes in intermediate-, adverse-risk, and <i>KMT2A</i>-rearranged AML","year":2021,"lang":"en","type":"article","venue":"Blood Advances","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ottawa Hospital","funders":"Office of Naval Research; Pharmacyclics; Sanofi Genzyme; Takeda Oncology; Genentech; Health Resources and Services Administration; National Institutes of Health; Omeros Corporation; Astellas Pharma; Adaptive Biotechnologies; Pfizer; Incyte; Kiadis Pharma; bluebird bio; National Institute of Allergy and Infectious Diseases; Angiocrine Bioscience; Karyopharm Therapeutics; Actinium Pharmaceuticals; Daiichi Sankyo Europe; National Cancer Institute; Gilead Sciences; Moonshot Research and Development Program; Sanofi; Cancer Moonshot; Medical College of Wisconsin; StemCyte; Memorial Sloan-Kettering Cancer Center; Weill Cornell Medical College; CSL Behring; Bristol-Myers Squibb; Legend Biotech; American Society of Clinical Oncology; GlaxoSmithKline; Be The Match Foundation; Seagen; Astellas Pharma US; Clinical and Translational Science Center, Weill Cornell Medical College; Amgen; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Medac; Jazz Pharmaceuticals","keywords":"Internal medicine; Medicine; Adverse effect; Myeloid leukemia; Oncology; Disease; Transplantation; Leukemia; Risk stratification; Hematopoietic stem cell transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009562871,0.000241693,0.000276942,0.0007725286,0.0002177596,0.0007486866,0.0003429202,0.0003597006,0.0009767732],"category_scores_gemma":[0.004055482,0.0001265401,0.0004159257,0.0005677866,0.0002577743,0.0003786976,0.0006038293,0.0004794711,0.0002644599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002939827,"about_ca_system_score_gemma":0.0002917053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003202098,"about_ca_topic_score_gemma":0.003676599,"domain_scores_codex":[0.9993925,0.000226192,0.00005502582,0.0001092259,0.00009448944,0.0001225169],"domain_scores_gemma":[0.9977472,0.0006219536,0.001017297,0.0001785311,0.0001454379,0.0002894711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002160826,0.00001175347,0.9976235,0.000002844532,0.00001953301,0.00002133096,0.00002538018,0.00007252114,0.0001041309,0.00001300696,0.00005402642,0.001835889],"study_design_scores_gemma":[0.00001301582,0.0001124196,0.9984514,0.000006262999,0.00004192624,0.000153294,0.00007976913,0.0007123598,0.0001835179,0.00008455622,0.0001569844,0.000004602604],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993095,0.0001583345,0.0001094665,0.00003275136,0.000005112539,0.000003238581,0.0001368315,0.0000028887,0.0002418454],"genre_scores_gemma":[0.9995323,0.00004333643,0.00005037422,0.00001266355,0.000009435584,0.000001998156,0.0002915607,0.000001793135,0.00005650874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003202098,"threshold_uncertainty_score":0.006366968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01414252623399647,"score_gpt":0.2856906914253413,"score_spread":0.2715481651913448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}