{"id":"W3201083468","doi":"10.1242/dmm.048929","title":"Implications of exosomes derived from cholesterol-accumulated astrocytes in Alzheimer's disease pathology","year":2021,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta","keywords":"Microvesicles; Neurodegeneration; Exosome; Secretion; Cell biology; Astrocyte; Biology; Alzheimer's disease; Amyloid precursor protein; Cholesterol; Microglia; Neuroglia; Neuroscience; Disease; Immunology; Medicine; Internal medicine; Endocrinology; Biochemistry; microRNA; Central nervous system; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003538578,0.0002704982,0.0002916699,0.000291934,0.0003904946,0.0005593051,0.0001088502,0.0004088302,0.0004913381],"category_scores_gemma":[0.0002724607,0.0001040637,0.0002654742,0.0001442013,0.000374158,0.0004567805,0.0004531976,0.0002882135,0.0001315085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001772991,"about_ca_system_score_gemma":0.0002478961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002281353,"about_ca_topic_score_gemma":0.0002424436,"domain_scores_codex":[0.9998146,0.00006228031,0.00003114754,0.00002004306,0.00004465991,0.00002737658],"domain_scores_gemma":[0.9998216,0.00003725869,0.00006044344,0.00001309401,0.00003662537,0.00003105773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00170886,0.0001353249,0.007528167,0.0003138434,0.00003630553,0.00384997,0.0002989775,0.0002075591,0.9767035,0.001408491,0.0001407373,0.007668232],"study_design_scores_gemma":[0.0001144195,0.0009375414,0.05940207,0.0001322668,0.0001359045,0.007872921,0.00108519,0.001301718,0.9178551,0.002633621,0.008495172,0.00003406336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906572,0.006706248,0.001249148,0.000234249,0.00005880901,0.00001898404,0.0001010165,0.00001303231,0.0009612886],"genre_scores_gemma":[0.9951406,0.003224093,0.000613306,0.00005838056,0.00001973734,0.00001221571,0.00006401769,0.000004134462,0.0008634579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005593051,"threshold_uncertainty_score":0.001871407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02456645904544469,"score_gpt":0.2671299955394937,"score_spread":0.242563536494049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}