{"id":"W3201083468","doi":"10.1242/dmm.048929","title":"Implications of exosomes derived from cholesterol-accumulated astrocytes in Alzheimer's disease pathology","year":2021,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta","keywords":"Microvesicles; Neurodegeneration; Exosome; Secretion; Cell biology; Astrocyte; Biology; Alzheimer's disease; Amyloid precursor protein; Cholesterol; Microglia; Neuroglia; Neuroscience; Disease; Immunology; Medicine; Internal medicine; Endocrinology; Biochemistry; microRNA; Central nervous system; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008748343,0.000282262,0.0002797202,0.00007353474,0.00006287585,0.000028021,0.0003567807,0.0001377094,0.00008384619],"category_scores_gemma":[0.00009520863,0.0003232607,0.0002161643,0.0001631326,0.00009740065,0.00002140823,0.0003033855,0.0001012426,0.000009217817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001936786,"about_ca_system_score_gemma":0.0003463543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001518761,"about_ca_topic_score_gemma":0.00003015582,"domain_scores_codex":[0.9980059,0.0002043163,0.000433095,0.0007903021,0.0001972942,0.0003691009],"domain_scores_gemma":[0.9980447,0.0000241766,0.0001485696,0.001092394,0.000175939,0.0005142694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003459938,0.000605455,0.002935824,0.00002159168,0.0001167811,0.0001669635,0.00005897742,0.0062247,0.9855661,0.002753963,0.00003327215,0.001170373],"study_design_scores_gemma":[0.001911094,0.00006773217,0.09255609,0.00007609297,0.0004445766,0.000004989279,0.0001209273,0.008965719,0.8195357,0.07567734,0.00005850786,0.0005812657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.924763,0.00886612,0.06467469,0.0002645681,0.00008640139,0.00029908,0.0009632887,0.00003210221,0.00005080913],"genre_scores_gemma":[0.9926043,0.0002306883,0.003709047,0.0004780218,0.00005951482,0.0001479821,0.00268884,0.00005838736,0.00002321236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1660305,"threshold_uncertainty_score":0.9999219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02456645904544469,"score_gpt":0.2671299955394937,"score_spread":0.242563536494049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}