{"id":"W3201084964","doi":"10.1158/1078-0432.ccr-21-1504","title":"First-In-Human Phase I Study of a Next-Generation, Oral, TGFβ Receptor 1 Inhibitor, LY3200882, in Patients with Advanced Cancer","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy; University of Texas MD Anderson Cancer Center; National Cancer Institute; Associazione Italiana per la Ricerca sul Cancro; Ministero della Salute; Eli Lilly and Company","keywords":"Gemcitabine; Pancreatic cancer; Cancer; Phases of clinical research; Receptor; Pancreatic disease; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007334059,0.0001532385,0.0003352819,0.00007816227,0.0001021109,0.00003156821,0.0002747247,0.0001466799,0.0002910176],"category_scores_gemma":[0.0006774716,0.0001399407,0.00005865152,0.000517972,0.000207399,0.00001402296,0.000203141,0.0003953671,0.000003160329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001017115,"about_ca_system_score_gemma":0.0007503394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004649636,"about_ca_topic_score_gemma":0.01147528,"domain_scores_codex":[0.9970818,0.0005560454,0.0006975596,0.0007190273,0.0005517364,0.0003938416],"domain_scores_gemma":[0.998278,0.00009421766,0.0001169976,0.0005325612,0.0008188608,0.0001594223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002118733,0.009384901,0.9276721,0.0000705225,0.00008279944,0.00001693475,0.0002086251,0.001197859,0.04787711,0.000002126441,0.002968223,0.0084],"study_design_scores_gemma":[0.06726506,0.01799543,0.6201123,0.0009219415,0.00006609539,4.024805e-7,0.00138581,0.0002133881,0.2628454,0.00002624277,0.02807937,0.001088561],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972415,0.001722212,0.000003969454,0.000120809,0.0001694738,0.0006662917,0.00005371133,0.000005706836,0.00001632185],"genre_scores_gemma":[0.9983637,0.0003635942,0.0001196612,0.00006940818,0.0003162433,0.0004418379,0.0001481546,0.0000339646,0.0001434288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3075598,"threshold_uncertainty_score":0.6403474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1678955923304999,"score_gpt":0.4950953371301059,"score_spread":0.327199744799606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}