{"id":"W3201171945","doi":"10.6004/jnccn.2021.7003","title":"Associations With Definitive Outcomes and Clinical Benefit of Cancer Drugs at the Time of Marketing Approval and in the Postmarketing Period","year":2021,"lang":"en","type":"article","venue":"Journal of the National Comprehensive Cancer Network","topic":"Economic and Financial Impacts of Cancer","field":"Economics, Econometrics and Finance","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Postmarketing surveillance; Clinical trial; Adverse effect; Internal medicine; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00189679,0.0001083133,0.0005038523,0.00004612507,0.000168533,0.00003251584,0.0001905658,0.00006408546,0.00006392331],"category_scores_gemma":[0.0007858514,0.00006618564,0.0001544201,0.0002241239,0.0002153325,0.0001152169,0.0001104265,0.0002956908,5.135354e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001749671,"about_ca_system_score_gemma":0.0001885435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008356743,"about_ca_topic_score_gemma":0.0003553996,"domain_scores_codex":[0.9985324,0.0001670452,0.0008741504,0.0001452555,0.0001304963,0.0001506214],"domain_scores_gemma":[0.9951025,0.002422192,0.001743397,0.00009190254,0.0006105511,0.00002942065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003666244,0.00003667866,0.9887035,0.00001825912,0.00037552,0.000001020555,0.0008292272,0.004165595,0.000006612329,0.003001858,0.001330455,0.001164683],"study_design_scores_gemma":[0.0008060889,0.00003356733,0.9930602,0.0001462052,0.00004521113,0.00001316904,0.000340651,0.0004846848,0.000006688411,0.002944073,0.00203787,0.0000815546],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9730817,0.01742649,0.000005243487,0.006797368,0.0002636449,0.0001334239,0.000243643,9.374019e-7,0.002047536],"genre_scores_gemma":[0.9948638,0.002594195,0.0001877966,0.001811899,0.0003051114,0.00000632865,0.000002034399,0.00001076319,0.000218058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0217821,"threshold_uncertainty_score":0.2698972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03868661739631556,"score_gpt":0.2948836666368336,"score_spread":0.2561970492405181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}