{"id":"W3201183251","doi":"10.1021/jacs.1c08057","title":"A New 1,5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility","year":2021,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Narodowe Centrum Nauki; Diamond Light Source; Vertex Pharmaceuticals; GlaxoSmithKline; UCB; Engineering and Physical Sciences Research Council; AstraZeneca; Takeda Pharmaceutical Company; Janssen Pharmaceuticals; Defence Science and Technology Laboratory; Syngenta Canada; Novartis; Pfizer","keywords":"Chemistry; Triazole; Compatibility (geochemistry); Polymerase; DNA; Combinatorial chemistry; DNA polymerase; Stereochemistry; Biochemistry; Organic chemistry; Chemical engineering","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002136499,0.0003036614,0.0003618381,0.0001539966,0.000160226,0.0003343917,0.0006187948,0.0005392616,0.001101728],"category_scores_gemma":[0.0004810649,0.0001881048,0.0002126346,0.0002485306,0.0002500465,0.000369617,0.0001540205,0.0006266297,0.0005732365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005303614,"about_ca_system_score_gemma":0.0003782428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009899843,"about_ca_topic_score_gemma":0.002254101,"domain_scores_codex":[0.9998161,0.00002638799,0.0000167558,0.00004693342,0.00006153,0.00003222086],"domain_scores_gemma":[0.9997632,0.00003556581,0.00008153799,0.00002997436,0.00003644306,0.00005323218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004827237,0.00001344871,0.00004399963,0.00002941907,0.000002003693,0.00005130668,0.00001184522,0.0001187167,0.9977718,0.0001426718,0.0000350704,0.001731387],"study_design_scores_gemma":[0.00002208101,0.0005507669,0.0005326418,0.000003450091,0.00001066927,0.000377072,0.000005852626,0.001258707,0.9945222,0.00002573175,0.002679193,0.00001153694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9577655,0.003019456,0.03208763,0.00021894,0.0001437569,0.0001471318,0.000300153,0.0005643068,0.005753084],"genre_scores_gemma":[0.9791501,0.0008309442,0.01530802,0.00005940476,0.00001420752,0.0000586576,0.0003599729,0.00004328697,0.004175402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001101728,"threshold_uncertainty_score":0.003848076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01105123001432598,"score_gpt":0.2571371614872436,"score_spread":0.2460859314729177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}