{"id":"W3201183251","doi":"10.1021/jacs.1c08057","title":"A New 1,5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility","year":2021,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Narodowe Centrum Nauki; Diamond Light Source; Vertex Pharmaceuticals; GlaxoSmithKline; UCB; Engineering and Physical Sciences Research Council; AstraZeneca; Takeda Pharmaceutical Company; Janssen Pharmaceuticals; Defence Science and Technology Laboratory; Syngenta Canada; Novartis; Pfizer","keywords":"Chemistry; Triazole; Compatibility (geochemistry); Polymerase; DNA; Combinatorial chemistry; DNA polymerase; Stereochemistry; Biochemistry; Organic chemistry; Chemical engineering","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009132846,0.0001862865,0.0004496152,0.000004184179,0.0001132562,0.00003475606,0.0004611894,0.00006678911,0.0006996865],"category_scores_gemma":[0.0001211212,0.0001267956,0.000570981,0.0004902339,0.0003056347,0.00006348453,0.0001097734,0.000591938,0.000003708577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001815244,"about_ca_system_score_gemma":0.0004480799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003887819,"about_ca_topic_score_gemma":0.000002877111,"domain_scores_codex":[0.9986497,0.0000198166,0.0004754726,0.0002413921,0.0003674056,0.0002462773],"domain_scores_gemma":[0.9980719,0.0001906412,0.000778899,0.0005357001,0.0001803269,0.0002425328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001333272,0.000226478,0.0005931291,0.00003049995,0.0001660376,0.000003388285,0.0001702694,0.00001605372,0.9915216,0.000006206252,0.005461455,0.001671534],"study_design_scores_gemma":[0.001202799,0.00001116893,0.0004639637,0.00006503522,0.0001260912,0.0001251747,0.0005564246,0.00003571532,0.9954582,0.0000954453,0.001694892,0.0001651167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954204,0.0001216337,0.0009019993,0.002587546,0.00002772814,0.00003327895,0.00002182872,0.00002260158,0.0008629872],"genre_scores_gemma":[0.9934363,0.00004790578,0.004941638,0.0005525344,0.0004021159,0.000003539019,0.00001157266,0.00001730766,0.0005870902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004039638,"threshold_uncertainty_score":0.7661077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01105123001432598,"score_gpt":0.2571371614872436,"score_spread":0.2460859314729177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}