{"id":"W3201196964","doi":"10.33774/chemrxiv-2021-c7xz5-v2","title":"Impairing Proliferation of Glioblastoma Multiforme with CD44+ Selective Conjugated Polymer Nanoparticles","year":2021,"lang":"en","type":"preprint","venue":"","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Windsor","funders":"Division of Materials Research; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institute of Standards and Technology; Canada Foundation for Innovation; Windsor Cancer Centre Foundation; University of Windsor; U.S. Department of Commerce; National Science Foundation","keywords":"CD44; Hyaluronic acid; Conjugated system; Population; Cancer research; Chemistry; Biophysics; Cell; Cancer stem cell; Stem cell; Medicine; Cell biology; Biology; Biochemistry; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006409716,0.000226366,0.0001007632,0.00009860886,0.00005000986,0.0001093422,0.00007096863,0.0001598058,0.0006169081],"category_scores_gemma":[0.00006676298,0.00007138558,0.00009650262,0.00005370068,0.00007733695,0.00009170477,0.0000986129,0.0001466216,0.000174656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000152041,"about_ca_system_score_gemma":0.0001004782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005492069,"about_ca_topic_score_gemma":0.0006350989,"domain_scores_codex":[0.9999613,0.000005168971,0.000002005521,0.00001018951,0.00001203218,0.000009265515],"domain_scores_gemma":[0.9999795,0.000004947819,0.000005721229,0.000002070638,0.000003348644,0.000004395329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002080055,0.000007628909,0.00003050789,0.00001477222,0.000001158391,0.00001431946,0.000004167568,0.00006062055,0.998799,0.00004643083,0.0000248474,0.0009757147],"study_design_scores_gemma":[0.000004691169,0.0001480216,0.0003659201,0.000001038241,0.000003622241,0.00004445952,0.000001731299,0.0007597017,0.9978871,0.000009260653,0.0007734338,0.000001135325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943066,0.0006009419,0.002964999,0.00005417635,0.00001916244,0.00002647238,0.00009585982,0.00007148742,0.001860291],"genre_scores_gemma":[0.9914522,0.0005894088,0.004204395,0.00002839052,0.000007550453,0.00003153075,0.0001692405,0.00002153017,0.003495749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006169081,"threshold_uncertainty_score":0.002063751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01322815448088522,"score_gpt":0.2624060380716992,"score_spread":0.249177883590814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}