{"id":"W3201205181","doi":"10.1016/j.nmd.2021.07.119","title":"DMD – ANIMAL MODELS","year":2021,"lang":"en","type":"article","venue":"Neuromuscular Disorders","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"","keywords":"Sanger sequencing; Genome editing; Biology; Reverse transcriptase; Stop codon; Exon; Primer (cosmetics); Plasmid; Genetics; Exon skipping; Duchenne muscular dystrophy; Coding region; Molecular biology; Population; CRISPR; Gene; Computational biology; Virology; Mutation; Medicine; Polymerase chain reaction; Chemistry; Alternative splicing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003945632,0.0001241364,0.00008832274,0.00001967782,0.0000472128,0.00002070742,0.0001097164,0.00007516211,0.00003381445],"category_scores_gemma":[0.00003516184,0.0001391356,0.0001309451,0.00009158668,0.00002472597,0.000002790279,0.00009461205,0.0000712964,0.00001035326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002857269,"about_ca_system_score_gemma":0.00003809815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005048776,"about_ca_topic_score_gemma":0.00003771456,"domain_scores_codex":[0.9992064,0.00002933892,0.0001043733,0.0003352091,0.0001126117,0.0002121189],"domain_scores_gemma":[0.9995201,0.000003719264,0.00001489433,0.0003580372,0.00003570979,0.00006754524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001717393,0.00007160475,0.0006102288,0.00002394478,0.00004720329,0.00001632675,0.00003684334,0.0133064,0.9784431,0.0003385353,0.001261756,0.005826815],"study_design_scores_gemma":[0.001685781,0.0004825208,0.01335994,0.00001672104,0.00007594666,0.00009424645,0.0002522483,0.007922966,0.6465913,0.001275845,0.3273139,0.0009285837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9512637,0.003484626,0.03782637,0.0003843385,0.0002247845,0.00009640012,0.000006623041,0.00003490009,0.006678237],"genre_scores_gemma":[0.997651,0.00076096,0.0006922405,0.0002948358,0.00008845575,0.00001055582,0.0000634282,0.00003258087,0.000405957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3318518,"threshold_uncertainty_score":0.5673787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006386999976338293,"score_gpt":0.259784377934933,"score_spread":0.2533973779585947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}