{"id":"W3201205181","doi":"10.1016/j.nmd.2021.07.119","title":"DMD – ANIMAL MODELS","year":2021,"lang":"en","type":"article","venue":"Neuromuscular Disorders","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"","keywords":"Sanger sequencing; Genome editing; Biology; Reverse transcriptase; Stop codon; Exon; Primer (cosmetics); Plasmid; Genetics; Exon skipping; Duchenne muscular dystrophy; Coding region; Molecular biology; Population; CRISPR; Gene; Computational biology; Virology; Mutation; Medicine; Polymerase chain reaction; Chemistry; Alternative splicing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001054912,0.001493189,0.0008758499,0.002285937,0.001176828,0.0007786686,0.001466171,0.00247749,0.02957256],"category_scores_gemma":[0.0004525164,0.0005771618,0.0008148518,0.0007268722,0.001118912,0.0007622579,0.00109258,0.002603864,0.01319873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006092484,"about_ca_system_score_gemma":0.0006590296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008761513,"about_ca_topic_score_gemma":0.002030902,"domain_scores_codex":[0.9989045,0.0001932904,0.0001245993,0.0002598538,0.0004082592,0.0001096544],"domain_scores_gemma":[0.9995958,0.00006234881,0.00008429264,0.00009511702,0.00006206536,0.0001004017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001179065,0.0008156652,0.001092158,0.001245496,0.0001559958,0.002834527,0.0001906073,0.0007585812,0.879614,0.02005836,0.0359378,0.05611778],"study_design_scores_gemma":[0.0003761141,0.001404108,0.00484509,0.0006136382,0.0003453747,0.0126976,0.0001318984,0.001040046,0.2792891,0.004844448,0.6943291,0.00008346717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.3152666,0.05265975,0.2560296,0.01033685,0.006591302,0.007685969,0.08197851,0.01455345,0.254898],"genre_scores_gemma":[0.3326505,0.04393991,0.1287871,0.005900166,0.0008614971,0.008723395,0.06955796,0.001756437,0.4078231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02957256,"threshold_uncertainty_score":0.09893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006386999976338293,"score_gpt":0.259784377934933,"score_spread":0.2533973779585947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}