{"id":"W3201218752","doi":"10.1186/s40478-021-01250-2","title":"Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study","year":2021,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Institute of Biomedical Imaging and Bioengineering; National Human Genome Research Institute; National Institute on Drug Abuse; National Institute of Mental Health; National Institute on Aging; University of California, San Francisco; Stichting MS Research; Canadian Institutes of Health Research; Pfizer; University of Washington; University of California, Los Angeles; Genentech; National Institutes of Health; Common Fund; H. Lundbeck A/S; Medical Research Council; Servier; Newcastle University; Northern California Institute for Research and Education; Universitat de Barcelona; F. Hoffmann-La Roche; Rush University; National Center for Advancing Translational Sciences; Novartis Pharmaceuticals Corporation; University of California, San Diego; Johns Hopkins University; NIH Office of the Director; York University; University of Miami; Northwestern University; Biogen; BioClinica; Emory University; U.S. Department of Veterans Affairs; University of Pennsylvania; Vanderbilt University; IXICO; University of Pittsburgh; Office of Research and Development; University of California, Davis; Foundation for the National Institutes of Health; University of Southern California; Eisai; Howard Hughes Medical Institute; Massachusetts General Hospital; Alzheimer's Research Trust; U.S. Department of Defense; Hersenstichting; Eli Lilly and Company; National Heart, Lung, and Blood Institute; North Bristol NHS Trust; Bristol-Myers Squibb; Alzheimer's Association; Wellcome Trust; University of California, Irvine; Meso Scale Diagnostics","keywords":"Hippocampal sclerosis; Genome-wide association study; Genetic association; Apolipoprotein E; Phenotype; Biology; Single-nucleotide polymorphism; Disease; Genotype; Genetics; Medicine; Pathology; Gene; Neuroscience; Temporal lobe","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008950726,0.0003552584,0.0003941035,0.0008222986,0.0004785015,0.0004957845,0.0004297972,0.0003776845,0.000938007],"category_scores_gemma":[0.001790531,0.0003478344,0.0004881956,0.001040577,0.0002877876,0.0001866433,0.0003843229,0.000397993,0.0003128895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002618119,"about_ca_system_score_gemma":0.0003117711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00740661,"about_ca_topic_score_gemma":0.008816512,"domain_scores_codex":[0.9993804,0.0001373325,0.00007438131,0.0002440068,0.0001029296,0.00006096505],"domain_scores_gemma":[0.9989365,0.0001711441,0.000266569,0.000273609,0.000193805,0.0001584178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004999755,0.00005600326,0.9948781,0.0000108891,0.000128294,0.0004424377,0.0001044819,0.00006778935,0.002111066,0.00003815231,0.00009273131,0.001569973],"study_design_scores_gemma":[0.00002102125,0.0002236598,0.9968777,0.000006276704,0.0001441488,0.001330934,0.00009156371,0.0003255361,0.0004590213,0.00003971708,0.00047539,0.000005240578],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998732,0.0002129921,0.0002971426,0.00001181838,0.000002922667,0.00001281846,0.0004751497,0.000004847735,0.0002501218],"genre_scores_gemma":[0.9986296,0.00008192767,0.0003122689,0.00001796163,0.000005650842,0.00001103513,0.0005911869,0.000005130803,0.0003452944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00740661,"threshold_uncertainty_score":0.014727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05142023896442494,"score_gpt":0.3185109746008854,"score_spread":0.2670907356364605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}