{"id":"W3201218752","doi":"10.1186/s40478-021-01250-2","title":"Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study","year":2021,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Institute of Biomedical Imaging and Bioengineering; National Human Genome Research Institute; National Institute on Drug Abuse; National Institute of Mental Health; National Institute on Aging; University of California, San Francisco; Stichting MS Research; Canadian Institutes of Health Research; Pfizer; University of Washington; University of California, Los Angeles; Genentech; National Institutes of Health; Common Fund; H. Lundbeck A/S; Medical Research Council; Servier; Newcastle University; Northern California Institute for Research and Education; Universitat de Barcelona; F. Hoffmann-La Roche; Rush University; National Center for Advancing Translational Sciences; Novartis Pharmaceuticals Corporation; University of California, San Diego; Johns Hopkins University; NIH Office of the Director; York University; University of Miami; Northwestern University; Biogen; BioClinica; Emory University; U.S. Department of Veterans Affairs; University of Pennsylvania; Vanderbilt University; IXICO; University of Pittsburgh; Office of Research and Development; University of California, Davis; Foundation for the National Institutes of Health; University of Southern California; Eisai; Howard Hughes Medical Institute; Massachusetts General Hospital; Alzheimer's Research Trust; U.S. Department of Defense; Hersenstichting; Eli Lilly and Company; National Heart, Lung, and Blood Institute; North Bristol NHS Trust; Bristol-Myers Squibb; Alzheimer's Association; Wellcome Trust; University of California, Irvine; Meso Scale Diagnostics","keywords":"Hippocampal sclerosis; Genome-wide association study; Genetic association; Apolipoprotein E; Phenotype; Biology; Single-nucleotide polymorphism; Disease; Genotype; Genetics; Medicine; Pathology; Gene; Neuroscience; Temporal lobe","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003294913,0.0001865539,0.0005409549,0.0003128004,0.0002830264,0.00004060892,0.0002045108,0.00008172691,0.000007594543],"category_scores_gemma":[0.001085597,0.0001597547,0.000119973,0.001154913,0.000164174,0.0000715504,0.00036944,0.0002214891,0.000001089232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001049157,"about_ca_system_score_gemma":0.0001155475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008324813,"about_ca_topic_score_gemma":0.0003172617,"domain_scores_codex":[0.9976771,0.0009029025,0.0004359015,0.0004967949,0.0002361672,0.0002511632],"domain_scores_gemma":[0.9972587,0.0006461729,0.0002879887,0.001185209,0.0004455465,0.0001763376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001136097,0.001698417,0.9845055,0.00001805041,0.00225843,0.000036643,0.0006252061,0.000007230893,0.009032892,0.00001459148,0.000003270189,0.001686136],"study_design_scores_gemma":[0.001607051,0.0006717969,0.9906977,0.00002517464,0.004416585,0.000004905143,0.0003676058,0.001536081,0.0002161246,0.0003216367,0.00001632764,0.0001190481],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854437,0.01228654,0.00001346722,0.000560872,0.000007874029,0.001374937,0.0002326371,0.00003498291,0.00004497376],"genre_scores_gemma":[0.9789301,0.01918545,0.001132493,0.00006060709,0.000007168569,0.0004745673,0.0001798034,0.00002026526,0.000009597191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008816767,"threshold_uncertainty_score":0.6514606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05142023896442494,"score_gpt":0.3185109746008854,"score_spread":0.2670907356364605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}