{"id":"W3201255177","doi":"10.1016/j.actbio.2021.09.021","title":"Stem cells immortalized by hTERT perform differently from those immortalized by SV40LT in proliferation, differentiation, and reconstruction of matrix microenvironment","year":2021,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; National Institutes of Health; Canadian Thoracic Society","keywords":"Telomerase reverse transcriptase; Stem cell; Cell biology; Decellularization; Telomerase; Extracellular matrix; Biology; Adult stem cell; Cellular differentiation; Senescence; Immortalised cell line; Mesenchymal stem cell; Immunology; Cancer research; Cell culture; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009103175,0.0002529815,0.0005712003,0.00008257388,0.00004647735,0.00003646668,0.00005160072,0.0001439689,0.0004092308],"category_scores_gemma":[0.000008546173,0.000204147,0.00005142286,0.0001108994,0.00007279115,0.00008456708,0.00003768119,0.00007032308,0.000003619898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007388321,"about_ca_system_score_gemma":0.0000303603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001600463,"about_ca_topic_score_gemma":0.00001326586,"domain_scores_codex":[0.998507,0.00008927962,0.0006007766,0.0003779011,0.0002183411,0.0002066613],"domain_scores_gemma":[0.9993886,0.00001649463,0.0001732277,0.0002665046,0.00004180634,0.000113416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001522169,0.0001757179,0.02929084,0.0001451416,0.0001292063,0.00001011215,0.0004280442,2.390003e-7,0.9662874,0.000006446364,0.002414529,0.0009600938],"study_design_scores_gemma":[0.003643035,0.0001282636,0.04435635,0.0002676873,0.000139171,0.00003798416,0.0001757508,0.0002158024,0.9493397,0.000006672575,0.0015115,0.0001780828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933513,0.00423198,0.0001735861,0.0004189687,0.001144514,0.0003762835,0.000263562,0.00003611073,0.00000365418],"genre_scores_gemma":[0.9958199,0.001038172,0.0003945045,0.0000189953,0.000142416,0.00003643817,0.00104918,0.00003254075,0.001467818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01694771,"threshold_uncertainty_score":0.8324872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007941949551246072,"score_gpt":0.231999691026376,"score_spread":0.22405774147513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}