{"id":"W3201255177","doi":"10.1016/j.actbio.2021.09.021","title":"Stem cells immortalized by hTERT perform differently from those immortalized by SV40LT in proliferation, differentiation, and reconstruction of matrix microenvironment","year":2021,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; National Institutes of Health; Canadian Thoracic Society","keywords":"Telomerase reverse transcriptase; Stem cell; Cell biology; Decellularization; Telomerase; Extracellular matrix; Biology; Adult stem cell; Cellular differentiation; Senescence; Immortalised cell line; Mesenchymal stem cell; Immunology; Cancer research; Cell culture; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003318217,0.0003702939,0.0004350593,0.0006488693,0.0002237201,0.0006938705,0.0001726306,0.0003864878,0.001322323],"category_scores_gemma":[0.0003795477,0.0002285932,0.0004140638,0.0003388555,0.0004066844,0.0003316563,0.000304426,0.0004276843,0.0007024874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001249363,"about_ca_system_score_gemma":0.0002648033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004995026,"about_ca_topic_score_gemma":0.0005801644,"domain_scores_codex":[0.9996685,0.00004935091,0.00005324633,0.00003812376,0.0001094996,0.0000813071],"domain_scores_gemma":[0.9995727,0.0001060257,0.00007161357,0.0000962126,0.00004807096,0.0001054092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001424433,0.00002232637,0.0006663359,0.00001268017,0.000006771384,0.00007801256,0.00006263089,0.00002545713,0.9980444,0.0001393062,0.00001688735,0.0007827354],"study_design_scores_gemma":[0.00001143015,0.0002343804,0.011156,0.000003663567,0.00002913915,0.0004477858,0.00008896773,0.0002339925,0.9855198,0.00009145459,0.002176803,0.000006726222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937474,0.0008161236,0.002476641,0.00003536765,0.00004266071,0.00002652519,0.0004307395,0.00009139335,0.002333209],"genre_scores_gemma":[0.9904909,0.0006149155,0.00207875,0.00005337934,0.00001364385,0.00004529913,0.001478203,0.00005387146,0.005171002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001322323,"threshold_uncertainty_score":0.004423618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007941949551246072,"score_gpt":0.231999691026376,"score_spread":0.22405774147513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}