{"id":"W3201363474","doi":"10.1016/j.clbc.2021.09.004","title":"Impact of the 21-Gene Recurrence Score Assay on the Treatment of Estrogen Receptor-Positive, HER2-Negative, Breast Cancer Patients With 1-3 Positive Nodes: A Prospective Clinical Utility Study","year":2021,"lang":"en","type":"article","venue":"Clinical Breast Cancer","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Positive Living North; Interior Health; BC Cancer Agency","funders":"Merck Sharp and Dohme; Bristol-Myers Squibb Canada; Genomic Health; Roche; Novartis; Amgen; Pfizer; Genentech; Celgene; AstraZeneca; Eli Lilly and Company; Sanofi; Merck","keywords":"Medicine; Breast cancer; Internal medicine; Estrogen receptor; Prospective cohort study; Estrogen; Oncology; Adjuvant; Chemotherapy; Cancer; Adjuvant therapy; Gynecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004148879,0.0005285757,0.0009151516,0.00002257327,0.0002130152,0.00002032518,0.0003881835,0.0002134812,0.0001732951],"category_scores_gemma":[0.0002407898,0.0002693163,0.0007800241,0.0004317792,0.001233383,0.00001383095,0.0002242194,0.0003097875,0.000003484165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003678957,"about_ca_system_score_gemma":0.001187665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002322272,"about_ca_topic_score_gemma":0.0009348519,"domain_scores_codex":[0.9957534,0.001234922,0.0009377913,0.001152541,0.0005005826,0.0004207437],"domain_scores_gemma":[0.9958174,0.0006395719,0.0007474342,0.001018792,0.001606101,0.0001707451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00689829,0.01132916,0.9579489,0.000009763486,0.003961045,0.00000298914,0.0003332783,0.00002100154,0.0001470621,0.000008000884,0.0002262006,0.01911428],"study_design_scores_gemma":[0.005162188,0.003466358,0.9840544,0.0002753056,0.0005274111,0.000008097898,0.0002161804,0.000004336478,0.005972863,0.0000169406,0.00002383714,0.0002720584],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863912,0.000409307,0.000009336047,0.0007023455,0.0004789623,0.001608159,0.01025973,0.000009860781,0.0001311371],"genre_scores_gemma":[0.9978974,0.0008094595,0.00006453922,0.0001821125,0.0004103956,0.0004659989,0.0000773045,0.00004407677,0.00004869467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0261055,"threshold_uncertainty_score":0.9999759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02736730519606758,"score_gpt":0.3569691101792106,"score_spread":0.3296018049831431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}