{"id":"W3201363474","doi":"10.1016/j.clbc.2021.09.004","title":"Impact of the 21-Gene Recurrence Score Assay on the Treatment of Estrogen Receptor-Positive, HER2-Negative, Breast Cancer Patients With 1-3 Positive Nodes: A Prospective Clinical Utility Study","year":2021,"lang":"en","type":"article","venue":"Clinical Breast Cancer","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Positive Living North; Interior Health; BC Cancer Agency","funders":"Merck Sharp and Dohme; Bristol-Myers Squibb Canada; Genomic Health; Roche; Novartis; Amgen; Pfizer; Genentech; Celgene; AstraZeneca; Eli Lilly and Company; Sanofi; Merck","keywords":"Medicine; Breast cancer; Internal medicine; Estrogen receptor; Prospective cohort study; Estrogen; Oncology; Adjuvant; Chemotherapy; Cancer; Adjuvant therapy; Gynecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003862733,0.0006137997,0.0006676472,0.0005236806,0.0002254254,0.0006488424,0.0004716039,0.0005728784,0.001085108],"category_scores_gemma":[0.008018826,0.0002490342,0.0007203079,0.0006499091,0.0004452946,0.0003723108,0.0002523392,0.0004844093,0.0002297701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003587385,"about_ca_system_score_gemma":0.0005398099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001551402,"about_ca_topic_score_gemma":0.002513011,"domain_scores_codex":[0.9973761,0.001939218,0.00009868095,0.0001838143,0.0003174415,0.00008472178],"domain_scores_gemma":[0.9937515,0.003764545,0.001124742,0.0004198989,0.0005022637,0.0004370819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04196084,0.0009999158,0.9351908,0.00007237635,0.000777595,0.0001076361,0.00007242565,0.0006213334,0.002493653,0.00007322705,0.0002275481,0.01740262],"study_design_scores_gemma":[0.001410614,0.02163266,0.9712034,0.00001678294,0.001336602,0.0003483068,0.0000808452,0.001503598,0.001576704,0.00007233307,0.0007968967,0.0000213271],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974924,0.001181841,0.00013965,0.00007678778,0.0000140994,0.00004340227,0.0002480156,0.000003153918,0.0008005954],"genre_scores_gemma":[0.9990243,0.0002875942,0.0001303995,0.00004570325,0.00002640051,0.0000155477,0.0002674716,0.000002582082,0.0002000047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003862733,"threshold_uncertainty_score":0.02042836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02736730519606758,"score_gpt":0.3569691101792106,"score_spread":0.3296018049831431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}