{"id":"W3201382684","doi":"10.1002/alz.051871","title":"Results of the first‐in‐human, randomized, double‐blind, placebo‐controlled phase 1b study of lumbar intrathecal bolus administrations of antisense oligonucleotide (ISIS 814907; BIIB080) targeting tau mRNA in patients with mild Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Bolus (digestion); Placebo; Intrathecal; Lumbar; Anesthesia; Randomized controlled trial; Double blind; Surgery; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003353139,0.002101553,0.004079812,0.0005404964,0.0007593105,0.001201113,0.0009449611,0.002367183,0.007948199],"category_scores_gemma":[0.002755171,0.001009967,0.001806855,0.0004079047,0.001266819,0.001088412,0.0003268147,0.002637302,0.001431295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000679977,"about_ca_system_score_gemma":0.001778572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005935582,"about_ca_topic_score_gemma":0.001780712,"domain_scores_codex":[0.9984044,0.0008391246,0.000148248,0.0002566219,0.0001333355,0.000218173],"domain_scores_gemma":[0.9981621,0.0005162498,0.0003449978,0.0001770389,0.0002338445,0.000565874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9717686,0.01359942,0.0004251626,0.0003542128,0.0005166534,0.00002440032,0.00003328729,0.0001682539,0.00463445,0.0000392924,0.0006212438,0.007815032],"study_design_scores_gemma":[0.8436716,0.1506791,0.003212251,0.00002122907,0.0005964157,0.00001986947,0.00001474446,0.0001772532,0.0008176668,0.00007762708,0.0006924339,0.00001975963],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688634,0.005172607,0.001453788,0.0005915291,0.0008108472,0.01421935,0.004451176,0.0002509725,0.004186475],"genre_scores_gemma":[0.9740122,0.002472332,0.002503298,0.001351611,0.0005151054,0.01157339,0.003050256,0.00005490545,0.004466951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007948199,"threshold_uncertainty_score":0.02658933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03139187610642053,"score_gpt":0.3192841974603379,"score_spread":0.2878923213539174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}