{"id":"W3201398398","doi":"","title":"A phase IV, open-label three-arm study investigating the impact of a combination of tenofovir disoproxil fumarate/emtricitabine with raltegravir or dolutegravir or elvitegravir/cobicistat on renal function in HIV-1 antiretroviral naïve patients.","year":2021,"lang":"en","type":"article","venue":"PubMed","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"","keywords":"Elvitegravir; Raltegravir; Dolutegravir; Emtricitabine; Cobicistat; Renal function; Urology; Tenofovir alafenamide; Medicine; Creatinine; Ritonavir; Pharmacology; Internal medicine; Gastroenterology; Human immunodeficiency virus (HIV); Viral load; Antiretroviral therapy; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001431239,0.00159775,0.002661558,0.0004409016,0.0004258768,0.00132548,0.001135876,0.001775315,0.007459634],"category_scores_gemma":[0.001198802,0.0006796307,0.001729744,0.0004872966,0.001103988,0.001371984,0.0003577032,0.003844023,0.001314547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007722275,"about_ca_system_score_gemma":0.001234679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001086445,"about_ca_topic_score_gemma":0.002360109,"domain_scores_codex":[0.9995168,0.000210454,0.00002525285,0.00009205415,0.00003669177,0.0001186361],"domain_scores_gemma":[0.9989212,0.0002010749,0.0001670512,0.0001147385,0.00007187372,0.0005240854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9439824,0.03234312,0.0006144145,0.0003330994,0.0009145007,0.0000415669,0.00005349776,0.0003975773,0.00568469,0.00008773091,0.0007698176,0.01477763],"study_design_scores_gemma":[0.7675151,0.2278666,0.002266526,0.00002296203,0.0003549388,0.000043699,0.00003295825,0.0003320078,0.0006045612,0.0001492541,0.0007922857,0.00001901505],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857391,0.003348907,0.000888549,0.0005513479,0.0004177234,0.004134173,0.00217283,0.0001405782,0.002606824],"genre_scores_gemma":[0.9825681,0.002240146,0.00225443,0.001253832,0.0003500092,0.004071689,0.002568081,0.00004834443,0.004645374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007459634,"threshold_uncertainty_score":0.02495497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05459871068159821,"score_gpt":0.3156500497431734,"score_spread":0.2610513390615752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}