{"id":"W3201522366","doi":"10.1158/1078-0432.ccr-21-2681","title":"Designing Clinical Trials for Combination Immunotherapy: A Framework for Glioblastoma","year":2021,"lang":"en","type":"review","venue":"Clinical Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Immunotherapy; Clinical trial; Glioblastoma; Medicine; Evasion (ethics); Immunosuppression; Immune system; Immunology; Cancer research; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03311969,0.001387113,0.004099329,0.002637268,0.0005182119,0.004124805,0.002992736,0.004671362,0.00251398],"category_scores_gemma":[0.02953919,0.0006773256,0.002093256,0.001617105,0.002567192,0.003733944,0.00241857,0.006465324,0.001152133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002921603,"about_ca_system_score_gemma":0.009695094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007930649,"about_ca_topic_score_gemma":0.001686701,"domain_scores_codex":[0.9849852,0.0114561,0.001430009,0.0005653853,0.001293035,0.0002702337],"domain_scores_gemma":[0.9772397,0.01857564,0.001447891,0.0004565578,0.00161428,0.0006658398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006687972,0.0002029245,0.0003528797,0.04814304,0.0006105698,0.0002963448,0.0003271344,0.002836324,0.001409468,0.105522,0.02198161,0.8176489],"study_design_scores_gemma":[0.001644822,0.00181896,0.001032832,0.1063623,0.001479346,0.001033508,0.0004602675,0.002465005,0.0008162402,0.1484147,0.7343592,0.0001128117],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"methods","genre_scores_codex":[0.0004104626,0.9631401,0.01360413,0.01636987,0.001117576,0.001350737,0.00008341912,0.00005875861,0.00386493],"genre_scores_gemma":[0.01132397,0.9087176,0.05901448,0.01289952,0.001559337,0.004904249,0.0001795097,0.00004488522,0.001356481],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.03311969,"threshold_uncertainty_score":0.1751558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7811385410991778,"score_gpt":0.7086286206520389,"score_spread":0.07250992044713889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}