{"id":"W3201538524","doi":"10.1007/978-1-0716-1783-0_15","title":"Generating Cerebral Organoids from Human Pluripotent Stem Cells","year":2021,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Stemcell Technologies","funders":"","keywords":"Organoid; Induced pluripotent stem cell; Human brain; Human Induced Pluripotent Stem Cells; Neuroscience; Biology; Embryonic stem cell; Computational biology; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007217017,0.0006730965,0.0005235107,0.0005842049,0.0003679821,0.000797957,0.001068044,0.0006136687,0.00506153],"category_scores_gemma":[0.0004281972,0.0004452632,0.0008945052,0.000374755,0.0004840691,0.0004258253,0.0007903584,0.001901081,0.002548697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002999925,"about_ca_system_score_gemma":0.0006932397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001085842,"about_ca_topic_score_gemma":0.002148509,"domain_scores_codex":[0.9997501,0.00002411484,0.00003253755,0.00005568108,0.00009211937,0.00004549323],"domain_scores_gemma":[0.9996827,0.00008960703,0.00003639904,0.00006893932,0.00004972687,0.00007282388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001781436,0.00004670185,0.0005134522,0.0002488898,0.00006508629,0.0008012609,0.0002017565,0.001027841,0.9775066,0.005006874,0.001571508,0.0128318],"study_design_scores_gemma":[0.00004896689,0.000115573,0.0009256779,0.00004575687,0.00009504046,0.0005732182,0.0000808723,0.001497762,0.972609,0.0009221971,0.02306505,0.00002090384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.4252558,0.006644891,0.4973973,0.001015521,0.001666066,0.002546465,0.01353714,0.003155646,0.04878112],"genre_scores_gemma":[0.7299746,0.007568176,0.2014385,0.0005058867,0.0001348295,0.001613012,0.01513326,0.0007829163,0.04284893],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.00506153,"threshold_uncertainty_score":0.01693255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02679580635991157,"score_gpt":0.3643698790513639,"score_spread":0.3375740726914523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}