{"id":"W3201609934","doi":"10.1182/blood.2022019117","title":"Outcomes of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; Agence Nationale de la Recherche","keywords":"Wiskott–Aldrich syndrome protein; Autoimmunity; Immunology; Wiskott–Aldrich syndrome; Genetic enhancement; Stem cell; Transplantation; Fludarabine; Hematopoietic stem cell transplantation; Biology; Medicine; Immune system; Cyclophosphamide; Internal medicine; Cell; Gene; Actin cytoskeleton; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003875225,0.0001616339,0.0005121907,0.0002134704,0.00004575735,0.00001140397,0.0001796553,0.00009890732,0.0004871836],"category_scores_gemma":[0.00001688829,0.0001283971,0.0002401797,0.0004898805,0.00005686102,0.00002829771,0.00004937553,0.0001231407,0.000119774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001971268,"about_ca_system_score_gemma":0.00009721788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001433651,"about_ca_topic_score_gemma":0.000001428458,"domain_scores_codex":[0.9985226,0.00003690862,0.000308845,0.000276811,0.0004562827,0.0003985364],"domain_scores_gemma":[0.9988715,0.0002709509,0.00007159467,0.0005399428,0.0001189744,0.0001270579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004431619,0.00204532,0.09501293,0.0008242035,0.0008724207,0.0002938319,0.001273075,0.000005292995,0.8905676,0.0001123307,0.001836692,0.006713162],"study_design_scores_gemma":[0.01563274,0.001982564,0.102864,0.00005998945,0.0001824735,0.0002300853,0.0003533775,0.00005933359,0.8736824,0.0003495455,0.004344488,0.0002589701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957948,0.0007728857,0.00002740968,0.0005589403,0.0001026128,0.001148418,0.00003012031,0.0001343158,0.001430499],"genre_scores_gemma":[0.969996,0.0004353816,0.0003272687,0.0001189914,0.00005856615,0.0001505612,0.00002870471,0.00007051914,0.02881397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02738347,"threshold_uncertainty_score":0.5334319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0410312759080021,"score_gpt":0.3152371416997443,"score_spread":0.2742058657917422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}