{"id":"W3201609934","doi":"10.1182/blood.2022019117","title":"Outcomes of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; Agence Nationale de la Recherche","keywords":"Wiskott–Aldrich syndrome protein; Autoimmunity; Immunology; Wiskott–Aldrich syndrome; Genetic enhancement; Stem cell; Transplantation; Fludarabine; Hematopoietic stem cell transplantation; Biology; Medicine; Immune system; Cyclophosphamide; Internal medicine; Cell; Gene; Actin cytoskeleton; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007630516,0.0003658984,0.0006018204,0.0001820561,0.0002035859,0.0003838242,0.0001531372,0.0004180542,0.0006163959],"category_scores_gemma":[0.0005230979,0.00005018773,0.000627102,0.0001438681,0.0002516873,0.0002153106,0.0001984692,0.0005287477,0.0001611716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003527428,"about_ca_system_score_gemma":0.0002803564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004260821,"about_ca_topic_score_gemma":0.0004971649,"domain_scores_codex":[0.9996825,0.0001179637,0.00003643185,0.00003279419,0.00006434743,0.000065873],"domain_scores_gemma":[0.9995795,0.00007154497,0.0001155466,0.00003062549,0.00003598516,0.0001667444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1525239,0.01001067,0.1556737,0.0009894276,0.002562667,0.006122244,0.0004747782,0.009180555,0.1100776,0.001547398,0.006006807,0.5448302],"study_design_scores_gemma":[0.01739934,0.3999473,0.5041903,0.0002724857,0.002528139,0.01161564,0.0002249926,0.007672308,0.04194281,0.001246362,0.012875,0.00008536758],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945851,0.002838074,0.0005856322,0.0001597035,0.00003508477,0.0001001986,0.0002647518,0.00002836838,0.001403225],"genre_scores_gemma":[0.9981759,0.0004444049,0.0001553922,0.0001297947,0.00002133121,0.00004970593,0.0006037077,0.000003958897,0.0004159002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007630516,"threshold_uncertainty_score":0.004035473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0410312759080021,"score_gpt":0.3152371416997443,"score_spread":0.2742058657917422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}