{"id":"W3201614454","doi":"10.21203/rs.2.23349/v1","title":"Modulation of Actin network and Tau phosphorylation by HDAC6 ZnF UBP domain","year":2020,"lang":"en","type":"preprint","venue":"","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto; National Chemical Laboratory; Department of Biotechnology, Ministry of Science and Technology, India","keywords":"Cell biology; Tau protein; Cytoskeleton; Cofilin; Phosphorylation; HDAC6; Microtubule; Aggresome; Microtubule-associated protein; Chemistry; Actin; Actin cytoskeleton; Biology; Alzheimer's disease; Cell; Ubiquitin; Biochemistry; Histone deacetylase; Histone; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005681969,0.000216908,0.0001160697,0.00009216415,0.0001397478,0.0002271815,0.0001748558,0.0001578083,0.006843237],"category_scores_gemma":[0.00005281642,0.00007236294,0.0001573432,0.0001055116,0.00009421477,0.0001206476,0.00009340093,0.0002366817,0.001804993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002280744,"about_ca_system_score_gemma":0.0001070282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007418985,"about_ca_topic_score_gemma":0.0009581822,"domain_scores_codex":[0.9999595,0.000003325285,0.000002788765,0.000008862929,0.00001223174,0.00001327349],"domain_scores_gemma":[0.9999747,0.000003067957,0.000007177049,0.000002887741,0.000004697102,0.000007506922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003469855,0.0000326465,0.0002875355,0.00007934942,0.000005860255,0.00005553389,0.00000770313,0.00005221814,0.9954463,0.0001038777,0.0004054815,0.003176551],"study_design_scores_gemma":[0.00002291862,0.00009175143,0.006810421,0.000006245974,0.000009973901,0.0001507531,0.00001228013,0.0005955856,0.9872705,0.00003700816,0.004989762,0.000002748916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798519,0.003838697,0.003516966,0.0003447725,0.0002331934,0.00003417881,0.002598588,0.0002587454,0.009322952],"genre_scores_gemma":[0.974546,0.002376777,0.002478864,0.00008621539,0.00005124048,0.00002774008,0.002673488,0.00007746687,0.0176823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006843237,"threshold_uncertainty_score":0.02289289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02932795333894112,"score_gpt":0.3112080039896264,"score_spread":0.2818800506506853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}