{"id":"W3201615812","doi":"10.1101/2021.09.14.460246","title":"Prolific Induction of IL-6 in Human Cells by SARS-CoV-2-derived Peptide is Attenuated by Recombinant Human Anti-inflammatory Cytokines made <i>in planta</i>","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Fanshawe College","funders":"FedDev Ontario; Compute Canada","keywords":"Immune system; Cytokine; Secretion; Recombinant DNA; Cytotoxic T cell; Cell culture; Biology; Peptide; Interleukin; Cancer research; Inflammation; Immunology; Internal medicine; Molecular biology; Medicine; Endocrinology; Gene; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002044929,0.0003472821,0.0002332942,0.0001100996,0.0000869022,0.0002029769,0.0001106942,0.0001848825,0.001466223],"category_scores_gemma":[0.0001163846,0.00008627327,0.0002405656,0.00008697582,0.0001611602,0.00007219498,0.0001212772,0.000509956,0.0004671132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001110004,"about_ca_system_score_gemma":0.0001125184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001503789,"about_ca_topic_score_gemma":0.0001768094,"domain_scores_codex":[0.9998486,0.00004436741,0.00001449441,0.00002222969,0.00003691006,0.00003326399],"domain_scores_gemma":[0.9999208,0.00002501872,0.00002071813,0.00001115692,0.000007676186,0.00001464715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001649889,0.00003477729,0.00006917556,0.00002793339,0.0000026607,0.00002605119,0.000006669354,0.00005265742,0.9989948,0.00001672884,0.00002087556,0.0005828154],"study_design_scores_gemma":[0.00003410362,0.001124199,0.001414771,0.000007914775,0.000009624792,0.0001952732,0.00001430757,0.0004260429,0.9945914,0.00001927998,0.002160547,0.000002420488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924052,0.001975044,0.003259432,0.0001281551,0.00005718927,0.00006903872,0.0005305387,0.00006783212,0.001507568],"genre_scores_gemma":[0.9923114,0.0008858345,0.003994646,0.00007635848,0.00002438721,0.00006621916,0.001273901,0.00001530411,0.001351963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001466223,"threshold_uncertainty_score":0.004904985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01362242949470843,"score_gpt":0.2232603039588028,"score_spread":0.2096378744640944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}