{"id":"W3201648970","doi":"10.3389/fmicb.2021.669709","title":"The Optimal Lipid Chain Length of a Membrane-Permeabilizing Lipopeptide Results From the Balance of Membrane Partitioning and Local Damage","year":2021,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Universiteit Gent; Fonds Wetenschappelijk Onderzoek; Albert-Ludwigs-Universität Freiburg; Fonds De La Recherche Scientifique - FNRS; Deutsche Forschungsgemeinschaft","keywords":"Membrane; Biophysics; Bacterial outer membrane; Liposome; Lipopeptide; Calcein; Chemistry; Lipid bilayer; Vesicle; Biology; Biochemistry; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004011088,0.0001665044,0.0003183194,0.00002374264,0.0001063933,0.00001286982,0.0002812471,0.0002046656,0.00000784584],"category_scores_gemma":[0.0002465461,0.0001118057,0.00008868085,0.0001151802,0.0007110822,0.000005845786,0.0001781518,0.000197419,4.188101e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001228285,"about_ca_system_score_gemma":0.00009864197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001108834,"about_ca_topic_score_gemma":0.0003383398,"domain_scores_codex":[0.9985121,0.0002901486,0.0004579158,0.0004065051,0.00005083453,0.000282535],"domain_scores_gemma":[0.9990926,0.0001273473,0.0001817619,0.000478995,0.00008494255,0.00003429466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003349561,0.00002826131,0.006000291,0.00001843567,0.00006988815,0.000004523078,0.0003290639,0.0002121132,0.9899689,0.00002414138,0.001150037,0.00185942],"study_design_scores_gemma":[0.001191923,0.00009640119,0.002506938,0.00004852143,0.00003993897,0.00002968677,0.001433888,0.0001170038,0.9788133,0.00001373731,0.0155737,0.0001349683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959812,0.001826337,0.0005365273,0.0004701276,0.0006131548,0.0001595814,0.0002886875,0.000004550579,0.0001198096],"genre_scores_gemma":[0.9949791,0.001091699,0.002974137,0.0001677367,0.0001979055,0.00001058602,0.0004031534,0.00001527905,0.0001604271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01442366,"threshold_uncertainty_score":0.4559305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005796902016073246,"score_gpt":0.213350380900056,"score_spread":0.2075534788839828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}