{"id":"W3201690512","doi":"10.1016/j.biopsych.2021.09.018","title":"Novel ADNP Syndrome Mice Reveal Dramatic Sex-Specific Peripheral Gene Expression With Brain Synaptic and Tau Pathologies","year":2021,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"European Regional Development Fund; Akademie Věd České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy; Naomi Foundation; Tel Aviv University; United States-Israel Binational Science Foundation; Ministry of Health, State of Israel; Ministry of Science and Technology, Israel; National Science Foundation","keywords":"Biology; Nap; FOXO3; Phenotype; Genetics; Gene; Cell biology; Neuroscience; Downregulation and upregulation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002017586,0.00137787,0.000528327,0.002127701,0.0004991055,0.0006757112,0.0007164843,0.0009301277,0.008080705],"category_scores_gemma":[0.0002767433,0.000447097,0.0004810613,0.0005467674,0.001043364,0.0004257979,0.0006999943,0.001417133,0.0009938149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000350342,"about_ca_system_score_gemma":0.0002969084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009012097,"about_ca_topic_score_gemma":0.003057227,"domain_scores_codex":[0.999432,0.0000468351,0.00007055055,0.0001883319,0.0001944376,0.00006786599],"domain_scores_gemma":[0.9993456,0.0001285542,0.0002382797,0.00005420077,0.0000494064,0.0001839514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002349577,0.00005330062,0.0008055976,0.00004130254,0.00002887794,0.001832538,0.00005642073,0.0000727745,0.994117,0.0005744041,0.0001850723,0.001997552],"study_design_scores_gemma":[0.0001502343,0.000319176,0.04782772,0.00005058962,0.0002109562,0.0243331,0.0003632152,0.001363701,0.9135804,0.001236071,0.01050969,0.00005522311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9718836,0.001722871,0.01206057,0.0003679357,0.0002042572,0.00007993785,0.006561825,0.0006549064,0.006464207],"genre_scores_gemma":[0.9657573,0.001232318,0.008425565,0.0002369245,0.00006696689,0.0001785583,0.003382153,0.0006684308,0.02005186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008080705,"threshold_uncertainty_score":0.02703261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01462994845994678,"score_gpt":0.2257658811153518,"score_spread":0.211135932655405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}