{"id":"W3201797647","doi":"10.1146/annurev-pharmtox-052120-084449","title":"Precision Medicine Approaches for Infantile-Onset Developmental and Epileptic Encephalopathies","year":2021,"lang":"en","type":"article","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Children's Hospital","funders":"","keywords":"Tuberous sclerosis; Epilepsy; Precision medicine; Medicine; Encephalopathy; Pediatrics; Intellectual disability; Bioinformatics; Psychiatry; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003455686,0.0008419729,0.001301427,0.002066808,0.0006749382,0.002297951,0.0013134,0.00209636,0.006294434],"category_scores_gemma":[0.00444692,0.0002635769,0.001094649,0.0008873859,0.001872909,0.002048192,0.002393567,0.003613671,0.002102542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001469116,"about_ca_system_score_gemma":0.001686777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009591536,"about_ca_topic_score_gemma":0.001786903,"domain_scores_codex":[0.9988574,0.0004032384,0.00008822352,0.0001644034,0.0003960432,0.00009067988],"domain_scores_gemma":[0.9972779,0.001552999,0.00030316,0.0002304365,0.0004771391,0.0001583779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00030819,0.0002170412,0.001076805,0.004267293,0.000326579,0.001409466,0.0003774158,0.001651806,0.009940595,0.09276433,0.04380534,0.8438551],"study_design_scores_gemma":[0.0001204886,0.0006130615,0.001384639,0.002456704,0.0002816427,0.003756449,0.0002630168,0.001321716,0.006847579,0.1100081,0.8728554,0.00009112928],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004378051,0.8845672,0.04565285,0.03318565,0.003015409,0.0001396552,0.000272176,0.000745749,0.02804339],"genre_scores_gemma":[0.07577406,0.8352033,0.05287725,0.02010752,0.004101202,0.0003642941,0.0005772907,0.0001518701,0.01084326],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006294434,"threshold_uncertainty_score":0.02105695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02155088194838613,"score_gpt":0.3049846492320589,"score_spread":0.2834337672836728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}