{"id":"W3201811380","doi":"10.1039/d1bm00799h","title":"Disease-specific extracellular matrix composition regulates placental trophoblast fusion efficiency","year":2021,"lang":"en","type":"article","venue":"Biomaterials Science","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université de Montréal; Institut National de la Recherche Scientifique; McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Decellularization; Extracellular matrix; Syncytiotrophoblast; Cell biology; Trophoblast; Cell fusion; Phenotype; Fibronectin; Adherens junction; Biology; Chemistry; Placenta; Immunology; Fetus; Cell; Pregnancy; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002603582,0.0001365286,0.0001579162,0.0002094597,0.0001357151,0.0004321851,0.00007969482,0.0001808964,0.0006187673],"category_scores_gemma":[0.0003980374,0.0001141157,0.00009838212,0.0001420022,0.0002178331,0.0001894147,0.0002098345,0.0002775452,0.000119203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002738658,"about_ca_system_score_gemma":0.0001838824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005578102,"about_ca_topic_score_gemma":0.0006087793,"domain_scores_codex":[0.9997997,0.00005847662,0.00002374329,0.00003701817,0.00004424102,0.00003686738],"domain_scores_gemma":[0.9998373,0.00004837677,0.00004790852,0.00001259753,0.00001864648,0.00003526312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007732396,0.00001044549,0.000732244,0.000008503085,0.000003023443,0.00001944485,0.00001792147,0.00004711746,0.9984514,0.00004417264,0.000009809521,0.0005785882],"study_design_scores_gemma":[0.00000997881,0.0001739948,0.02266773,0.000004462647,0.00001833453,0.0001719808,0.00009735049,0.001786861,0.9742919,0.00006494491,0.0007078142,0.000004599119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978528,0.0004823085,0.001041247,0.00003402419,0.000006146216,0.000009596387,0.00006720606,0.00001393239,0.0004927775],"genre_scores_gemma":[0.9985241,0.00033768,0.0006978473,0.00002097024,0.000001973159,0.00001333702,0.00007230293,0.000006744399,0.0003249206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006187673,"threshold_uncertainty_score":0.00206995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01516846341175999,"score_gpt":0.2609100998690506,"score_spread":0.2457416364572906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}