{"id":"W3201838411","doi":"10.1016/j.annonc.2021.08.1314","title":"904P ACCURACY: A phase II trial of AL101, a selective gamma secretase inhibitor, in subjects with recurrent/metastatic (R/M) adenoid cystic carcinoma (ACC) harboring Notch activating mutations (Notchmut): Results of 6-mg cohort","year":2021,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Salivary Gland Tumors Diagnosis and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Adenoid cystic carcinoma; Gamma secretase; Internal medicine; Phases of clinical research; Cancer research; Oncology; Carcinoma; Clinical trial; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001222411,0.001537008,0.0016597,0.0003385015,0.0003458111,0.001043409,0.001002273,0.00129148,0.00489992],"category_scores_gemma":[0.0008651406,0.0005471892,0.001270458,0.0003654897,0.0008034131,0.0008249234,0.0003818079,0.003137515,0.001657399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007935824,"about_ca_system_score_gemma":0.001124726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001663992,"about_ca_topic_score_gemma":0.003905547,"domain_scores_codex":[0.9996024,0.0001746244,0.00001698639,0.0000882309,0.00004536193,0.00007229146],"domain_scores_gemma":[0.9995727,0.00007026348,0.00008223866,0.00004901547,0.00003585875,0.0001899276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7903973,0.02267209,0.01798272,0.0005263041,0.00418263,0.0002686339,0.000239069,0.002241413,0.03302817,0.0003354282,0.009016205,0.1191101],"study_design_scores_gemma":[0.7255306,0.2218919,0.0357959,0.00005570363,0.002961869,0.0005318368,0.0001527796,0.001778284,0.004290795,0.0005857529,0.006349108,0.00007558055],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904607,0.002466623,0.0004391918,0.001063968,0.0001732581,0.0006036607,0.002236477,0.0002095556,0.00234663],"genre_scores_gemma":[0.9853086,0.002684994,0.001192934,0.001266514,0.0001917947,0.0006537905,0.004515569,0.00007373793,0.004112111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00489992,"threshold_uncertainty_score":0.01639187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07139578323044105,"score_gpt":0.3871296237619073,"score_spread":0.3157338405314663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}