{"id":"W3201854675","doi":"10.1016/j.jconrel.2021.10.001","title":"Dissolving microneedle patches loaded with amphotericin B microparticles for localised and sustained intradermal delivery: Potential for enhanced treatment of cutaneous fungal infections","year":2021,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":122,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"China Scholarship Council; Queen's University; Queen's University Belfast","keywords":"Amphotericin B; Candida albicans; Bioavailability; Dosage form; Pharmacology; Drug delivery; Drug; In vivo; Chemistry; Microbiology; Medicine; Biology; Antifungal; Organic chemistry; Biotechnology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001802657,0.0002410437,0.0007635939,0.0001123449,0.0002189637,0.00002502768,0.00008337418,0.0001451894,0.00006178845],"category_scores_gemma":[0.0001395268,0.0001866736,0.0002960093,0.0001044578,0.0001973768,0.0001366045,0.00001420472,0.0001975384,4.125245e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001262769,"about_ca_system_score_gemma":0.0003143581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000747813,"about_ca_topic_score_gemma":0.00001647493,"domain_scores_codex":[0.9983435,0.0002317555,0.0007263139,0.0002008502,0.0001267086,0.0003709226],"domain_scores_gemma":[0.9975452,0.0009582987,0.0005214458,0.0001011387,0.0006657341,0.0002081111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0487869,0.001645208,0.000335932,0.0001485739,0.001697554,0.0003876729,0.0007574399,0.01350472,0.9220681,0.00003553758,0.00007772801,0.01055467],"study_design_scores_gemma":[0.07101777,0.003904791,0.00007745401,0.00006224307,0.00244079,0.0007966224,0.001508962,0.01284435,0.9054965,0.000121743,0.001486366,0.0002424205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9097409,0.002771929,0.08539354,0.0006170705,0.0003304329,0.0009962252,0.0001252809,0.00001169328,0.00001292338],"genre_scores_gemma":[0.9958004,0.0009800384,0.002516375,0.0002245518,0.0002199256,0.00007294265,0.00001302701,0.00002812478,0.0001446254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08605948,"threshold_uncertainty_score":0.7612329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02646592893394397,"score_gpt":0.3410932243156525,"score_spread":0.3146272953817085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}