{"id":"W3201854675","doi":"10.1016/j.jconrel.2021.10.001","title":"Dissolving microneedle patches loaded with amphotericin B microparticles for localised and sustained intradermal delivery: Potential for enhanced treatment of cutaneous fungal infections","year":2021,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":122,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"China Scholarship Council; Queen's University; Queen's University Belfast","keywords":"Amphotericin B; Candida albicans; Bioavailability; Dosage form; Pharmacology; Drug delivery; Drug; In vivo; Chemistry; Microbiology; Medicine; Biology; Antifungal; Organic chemistry; Biotechnology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000880688,0.0001541646,0.0001866775,0.0001136861,0.00008746754,0.0002262061,0.0001411465,0.0002976132,0.0005950882],"category_scores_gemma":[0.0001095506,0.00008930342,0.000121584,0.00006726175,0.0001002872,0.0002410064,0.0001550598,0.0002546481,0.0001591362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001234382,"about_ca_system_score_gemma":0.00009476486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003223062,"about_ca_topic_score_gemma":0.0005998611,"domain_scores_codex":[0.9999474,0.000005083437,0.000003381994,0.00001549486,0.00001627133,0.00001228712],"domain_scores_gemma":[0.9999552,0.00001159713,0.00001388241,0.000003428847,0.000007115586,0.00000886656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000527473,0.00001688515,0.00002580309,0.00004437284,0.000002242916,0.00003258157,0.000007435026,0.00003422278,0.9957505,0.00002521219,0.00002727646,0.003980618],"study_design_scores_gemma":[0.00002472277,0.0005223316,0.001383964,0.000008994415,0.00002051124,0.0002380498,0.00001350912,0.00106726,0.9953857,0.00001873008,0.001310147,0.000006144917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873007,0.00491313,0.006526287,0.00008839797,0.0000573635,0.00004244804,0.00005912422,0.00008179749,0.0009308853],"genre_scores_gemma":[0.9929473,0.001408908,0.004094279,0.00004421347,0.00001324496,0.00001708451,0.00002736468,0.00001242137,0.001435101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005950882,"threshold_uncertainty_score":0.001990795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02646592893394397,"score_gpt":0.3410932243156525,"score_spread":0.3146272953817085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}