{"id":"W3201861214","doi":"10.1007/s43032-021-00735-8","title":"High Maternal Serum Estradiol in First Trimester of Multiple Pregnancy Contributes to Small for Gestational Age via DNMT1-Mediated CDKN1C Upregulation","year":2021,"lang":"en","type":"article","venue":"Reproductive Sciences","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key New Drug Creation and Manufacturing Program, Ministry of Science and Technology; National Key Research and Development Program of China; Queen's University; National Natural Science Foundation of China","keywords":"Andrology; Offspring; Small for gestational age; Fetus; Gestation; Pregnancy; Medicine; Placenta; Miscarriage; Birth weight; Umbilical cord; Cord blood; Low birth weight; Gestational age; Obstetrics; Biology; Internal medicine; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003881502,0.000100505,0.0002408503,0.0001274976,0.0000771881,0.0000237051,0.00009383909,0.00004859984,0.00001205919],"category_scores_gemma":[0.004555244,0.00008562181,0.0000475597,0.0005265032,0.0001619197,0.0001188293,0.00004037885,0.00005874868,0.000003352691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005172285,"about_ca_system_score_gemma":0.000191594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003427725,"about_ca_topic_score_gemma":0.0002236106,"domain_scores_codex":[0.9987169,0.00004172817,0.0002855807,0.0005142903,0.0002237692,0.0002177573],"domain_scores_gemma":[0.9987156,0.0006433984,0.00009844572,0.0001994195,0.0002756152,0.00006755007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003584651,0.0002653619,0.9560464,0.0001523633,0.00004319355,0.00006753994,0.0005718351,0.003507432,0.03191271,0.0007003071,0.0001200903,0.006254305],"study_design_scores_gemma":[0.001300527,0.0002544216,0.8602721,0.0004968147,0.00002176937,0.00002293641,0.0000746578,0.0009693713,0.1351325,0.001309639,0.0000624248,0.00008281747],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991528,0.0004609965,0.004527323,0.002410985,0.0002275564,0.0006423777,0.0001006524,0.00002393325,0.00007820735],"genre_scores_gemma":[0.9860715,0.00001126039,0.01338905,0.00005716442,0.0001015161,0.00005631209,0.00008078726,0.000006694927,0.0002257299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1032198,"threshold_uncertainty_score":0.5453381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03659986724974544,"score_gpt":0.2844338897560655,"score_spread":0.24783402250632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}