{"id":"W3201861214","doi":"10.1007/s43032-021-00735-8","title":"High Maternal Serum Estradiol in First Trimester of Multiple Pregnancy Contributes to Small for Gestational Age via DNMT1-Mediated CDKN1C Upregulation","year":2021,"lang":"en","type":"article","venue":"Reproductive Sciences","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key New Drug Creation and Manufacturing Program, Ministry of Science and Technology; National Key Research and Development Program of China; Queen's University; National Natural Science Foundation of China","keywords":"Andrology; Offspring; Small for gestational age; Fetus; Gestation; Pregnancy; Medicine; Placenta; Miscarriage; Birth weight; Umbilical cord; Cord blood; Low birth weight; Gestational age; Obstetrics; Biology; Internal medicine; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001160644,0.0001674417,0.0002249099,0.0001784398,0.00009292901,0.0002552032,0.0001186758,0.000135125,0.001809002],"category_scores_gemma":[0.0003527064,0.0001478056,0.0001752813,0.00009447253,0.0001478201,0.00009822886,0.0001838519,0.0002768069,0.0001759059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003014607,"about_ca_system_score_gemma":0.0001834943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001410675,"about_ca_topic_score_gemma":0.001796847,"domain_scores_codex":[0.9999191,0.00001282834,0.000007869435,0.00002451136,0.00001952431,0.0000161389],"domain_scores_gemma":[0.9997872,0.00003355997,0.0001030232,0.00001924046,0.00001825713,0.0000388945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007364637,0.00004344974,0.03572362,0.0001320863,0.00003979564,0.0005902243,0.00007157191,0.0001092464,0.9520839,0.0001525451,0.0001851743,0.01013183],"study_design_scores_gemma":[0.00004458385,0.0005134377,0.5430279,0.00004200634,0.00009637112,0.003547854,0.0001364669,0.001500861,0.4455816,0.0002763766,0.005219342,0.00001322866],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940049,0.003387229,0.001176579,0.0001131992,0.00002384724,0.00000951437,0.0004393939,0.00004181085,0.0008034843],"genre_scores_gemma":[0.9970975,0.001029697,0.0005730581,0.00002493497,0.000005389722,0.000008983877,0.000169921,0.000007048648,0.001083411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001809002,"threshold_uncertainty_score":0.006051719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03659986724974544,"score_gpt":0.2844338897560655,"score_spread":0.24783402250632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}